@misc{oai:repo.qst.go.jp:00072748,
 author = {Akinori, Morita and Wang, Bing and Tanaka, Kaoru and Katsube, Takanori and Murakami, Masahiro and ラマダーニ・ドゥウィ and Shimokawa, Takashi and Nenoi, Mitsuru and Ochi Shintaro and 森田 明典 and 王 冰 and 田中 薫 and 勝部 孝則 and 村上 正弘 and 下川 卓志 and 根井 充 and 越智 進太郎},
 month = {Apr},
 note = {The remarkable progress toward high-precision radiation therapy has been made in recent years. However, in order to prevent adverse events occurring in organs at risk, the risks of radiation injury in the normal tissues still determine the limits of the tolerable dose. We explored some compounds that target p53, and found several radioprotectors that control p53 activity. On the other hand, it is known that high LET radia6on above 85 keV/μm shows a p53-independent cell killing effect on some cultured cells; however, there is no report so far about the radioprptective effects of p53 regulatory agents on heavy ion-irradiated mice. In this study, we used two p53 regulatory agents. One is a p53 inhibitor, sodium orthovanadate (vanadate), which has a potent radioprotective activity for bone marrow death in total body irradiated mice, and the other a transcriptional modulator for p53, 5-chloro-8-quinolinol (5CHQ), having a potent radioprotective ac6vity for gastrointestinal death in abdominally irradiated mice. We would examine the effects of these radioprotectors on heavy ion-irradiated mice. In this fiscal year, we actually found that vanadate protects mice that were total body irradiated with carbon ion beams. The radioprotective effect of 5CHQ on heavy ion-irradiated mice is currently under investigation., 平成29 年度HIMAC 共同利用研究成果発表会},
 title = {細胞死制御剤による重粒子放射線防護効果のマウス個体レベルでの検討},
 year = {2018}
}