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Design, Synthesis, and Evaluation of Radioprotecting Agents Targeting p53 Based on Zinc Enzyme Research, Machine Learning, and Random Screening
https://repo.qst.go.jp/records/72676
https://repo.qst.go.jp/records/72676448bcaab-19ca-4c39-b408-9c6cb2976b2c
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-03-06 | |||||
| タイトル | ||||||
| タイトル | Design, Synthesis, and Evaluation of Radioprotecting Agents Targeting p53 Based on Zinc Enzyme Research, Machine Learning, and Random Screening | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
青木伸
× 青木伸× 寺岡達朗× 西友里恵× 佐藤秀哉× 水野皓介× 嵯峨裕× 氏田将平× 山川知晃× 越智進太郎× 大和田勇人× Wang, Bing× Akinori, Morita× 王 冰× 森田 明典 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In radiation therapy, adverse side effects are often induc Therefore, development of radioprotective drugs that can protect normal cells from radiation and thus suppress adverse side effects would be highly desirable. The radiation-induced cell death of normal cells is caused, at least in part, by apoptosis, which undergoes via activation of p53 and increase in the p53 protein, a zinc-containing transcriptional factor, in response to cellular damage. In this paper, we report on the radioprotective activity of 8-hydroxyquinoline (8HQ) derivatives that were designed so as to interact with the Zn2+ in p53. and protect MOLT-4 cells against g-ray radiation (10 Gy), accompanied by a low cytotoxicity. The details of design, synthesis, and biological activities of derivatives will be presented. The results of the prediction of radioprotective activity and toxicity of these drugs and random screening from the compound library of Drug Discovery Initiative (DDI), the University of Tokyo, will also be presented. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第３５回メディシナルケミストリーシンポジウム名古屋 | |||||
| 発表年月日 | ||||||
| 日付 | 2017-10-25 | |||||
| 日付タイプ | Issued | |||||
