@misc{oai:repo.qst.go.jp:00072676,
 author = {青木伸 and 寺岡達朗 and 西友里恵 and 佐藤秀哉 and 水野皓介 and 嵯峨裕 and 氏田将平 and 山川知晃 and 越智進太郎 and 大和田勇人 and Wang, Bing and Akinori, Morita and 王 冰 and 森田 明典},
 month = {Oct},
 note = {In radiation therapy, adverse side effects are often induc   Therefore, development of radioprotective drugs that can protect normal cells from radiation and thus suppress adverse side effects would be highly desirable.  The radiation-induced cell death of normal cells is caused, at least in part, by apoptosis, which undergoes via activation of p53 and increase in the p53 protein, a zinc-containing transcriptional factor, in response to cellular damage.  In this paper, we report on the radioprotective activity of 8-hydroxyquinoline (8HQ) derivatives that were designed so as to interact with the Zn2+ in p53. and protect MOLT-4 cells against g-ray radiation (10 Gy), accompanied by a low cytotoxicity.  The details of design, synthesis, and biological activities of derivatives will be presented.  The results of the prediction of radioprotective activity and toxicity of these drugs and random screening from the compound library of Drug Discovery Initiative (DDI), the University of Tokyo, will also be presented., 第３５回メディシナルケミストリーシンポジウム名古屋},
 title = {Design, Synthesis, and Evaluation of Radioprotecting Agents Targeting p53 Based on Zinc Enzyme Research, Machine Learning, and Random Screening},
 year = {2017}
}