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重粒子線によるDNA損傷形態に関する研究
https://repo.qst.go.jp/records/72655
https://repo.qst.go.jp/records/72655accc121e-4aac-4709-8601-b5155fb70122
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-02-08 | |||||
| タイトル | ||||||
| タイトル | 重粒子線によるDNA損傷形態に関する研究 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
赤松, 憲
× 赤松, 憲× 鹿園, 直哉× 小池, 学× 平山, 亮一× 藤本, 浩文× 赤松 憲× 鹿園 直哉× 小池 学× 平山 亮一× 藤本 浩文 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Clustered damage site, that is a DNA region with multiple lesions within a few helical turns, is believed to hardly be repaired. However, chemical and spatial details of them are not known. We have developed a method-ology for estimating localization of AP sites using fluo-rescence resonance energy transfer (FRET). We have already found that carbon ion can produce clustered DNA damage regions within a track using dry DNA film as an irradiation sample by the FRET methodology. We applied the methodology to a cell-mimetic buffered DNA solution irradiated with carbon ion beam with LET of ~90 keV/m. As a result, we found that the carbon ion tends to produce more clustered AP sites compared with heat-acid treated DNA with Poisson distributed AP site. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | H27年度HIMAC共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2016-04-26 | |||||
| 日付タイプ | Issued | |||||
