{"_buckets": {"deposit": "96d3ed84-bb49-4c67-ad19-be86aef68b4f"}, "_deposit": {"created_by": 1, "id": "72460", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "72460"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00072460", "sets": ["28"]}, "author_link": ["713655", "713661", "713659", "713660", "713658", "713656", "713657"], "item_10005_date_7": {"attribute_name": "発表年月日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2017-09-21", "subitem_date_issued_type": "Issued"}]}, "item_10005_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "In order to investigate the effects of a cardiomyopathy-causing mutation E244D of troponin (Tn) T on the structure of thin filaments, small-angle x-ray scattering measurements were carried out on bovine cardiac thin filaments, in which the endogenous Tn was exchanged with human cardiac Tn containing the wild-type (WT) or E244D mutant (MT) of TnT, in the –Ca2+ and +Ca2+ states. Analysis by model calculation shows that while there are no structural differences between the WT and MT in the –Ca2+ state, tropomyosin (Tm) of the MT moves closer to the fiber axis than that of the WT in the +Ca2+ state. Since Tm directly controls myosin binding, this change would modulate the force production process, leading to functional aberration reported for the E244D mutation.", "subitem_description_type": "Abstract"}]}, "item_10005_description_6": {"attribute_name": "会議概要（会議名, 開催地, 会期, 主催者等）", "attribute_value_mlt": [{"subitem_description": "第55回日本生物物理学会年会", "subitem_description_type": "Other"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "松尾, 龍人"}], "nameIdentifiers": [{"nameIdentifier": "713655", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "松尾龍人"}], "nameIdentifiers": [{"nameIdentifier": "713656", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "河野, 史明"}], "nameIdentifiers": [{"nameIdentifier": "713657", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤原, 悟"}], "nameIdentifiers": [{"nameIdentifier": "713658", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "松尾 龍人", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "713659", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "河野 史明", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "713660", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤原 悟", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "713661", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "conference object", "resourceuri": "http://purl.org/coar/resource_type/c_c94f"}]}, "item_title": "Effects of E244D mutation of cardiac troponin T on the structure of thin filaments by small-angle x-ray scattering", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Effects of E244D mutation of cardiac troponin T on the structure of thin filaments by small-angle x-ray scattering"}]}, "item_type_id": "10005", "owner": "1", "path": ["28"], "permalink_uri": "https://repo.qst.go.jp/records/72460", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-09-25"}, "publish_date": "2017-09-25", "publish_status": "0", "recid": "72460", "relation": {}, "relation_version_is_last": true, "title": ["Effects of E244D mutation of cardiac troponin T on the structure of thin filaments by small-angle x-ray scattering"], "weko_shared_id": -1}