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  1. 学会発表・講演等
  2. ポスター発表

Effects of E244D mutation of cardiac troponin T on the structure of thin filaments by small-angle x-ray scattering

https://repo.qst.go.jp/records/72460
https://repo.qst.go.jp/records/72460
8bdbb901-f80c-4342-b215-34afe233d63c
Item type 会議発表用資料 / Presentation(1)
公開日 2017-09-25
タイトル
タイトル Effects of E244D mutation of cardiac troponin T on the structure of thin filaments by small-angle x-ray scattering
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 松尾, 龍人

× 松尾, 龍人

WEKO 713655

松尾, 龍人

Search repository
松尾龍人

× 松尾龍人

WEKO 713656

松尾龍人

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河野, 史明

× 河野, 史明

WEKO 713657

河野, 史明

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藤原, 悟

× 藤原, 悟

WEKO 713658

藤原, 悟

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松尾 龍人

× 松尾 龍人

WEKO 713659

en 松尾 龍人

Search repository
河野 史明

× 河野 史明

WEKO 713660

en 河野 史明

Search repository
藤原 悟

× 藤原 悟

WEKO 713661

en 藤原 悟

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抄録
内容記述タイプ Abstract
内容記述 In order to investigate the effects of a cardiomyopathy-causing mutation E244D of troponin (Tn) T on the structure of thin filaments, small-angle x-ray scattering measurements were carried out on bovine cardiac thin filaments, in which the endogenous Tn was exchanged with human cardiac Tn containing the wild-type (WT) or E244D mutant (MT) of TnT, in the –Ca2+ and +Ca2+ states. Analysis by model calculation shows that while there are no structural differences between the WT and MT in the –Ca2+ state, tropomyosin (Tm) of the MT moves closer to the fiber axis than that of the WT in the +Ca2+ state. Since Tm directly controls myosin binding, this change would modulate the force production process, leading to functional aberration reported for the E244D mutation.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 第55回日本生物物理学会年会
発表年月日
日付 2017-09-21
日付タイプ Issued
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