{"created":"2023-05-15T14:53:09.594008+00:00","id":72460,"links":{},"metadata":{"_buckets":{"deposit":"96d3ed84-bb49-4c67-ad19-be86aef68b4f"},"_deposit":{"created_by":1,"id":"72460","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72460"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072460","sets":["10:28"]},"author_link":["713655","713661","713659","713660","713658","713656","713657"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017-09-21","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In order to investigate the effects of a cardiomyopathy-causing mutation E244D of troponin (Tn) T on the structure of thin filaments, small-angle x-ray scattering measurements were carried out on bovine cardiac thin filaments, in which the endogenous Tn was exchanged with human cardiac Tn containing the wild-type (WT) or E244D mutant (MT) of TnT, in the –Ca2+ and +Ca2+ states. Analysis by model calculation shows that while there are no structural differences between the WT and MT in the –Ca2+ state, tropomyosin (Tm) of the MT moves closer to the fiber axis than that of the WT in the +Ca2+ state. Since Tm directly controls myosin binding, this change would modulate the force production process, leading to functional aberration reported for the E244D mutation.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第55回日本生物物理学会年会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松尾, 龍人"}],"nameIdentifiers":[{"nameIdentifier":"713655","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松尾龍人"}],"nameIdentifiers":[{"nameIdentifier":"713656","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河野, 史明"}],"nameIdentifiers":[{"nameIdentifier":"713657","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤原, 悟"}],"nameIdentifiers":[{"nameIdentifier":"713658","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松尾 龍人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713659","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河野 史明","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713660","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤原 悟","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713661","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Effects of E244D mutation of cardiac troponin T on the structure of thin filaments by small-angle x-ray scattering","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of E244D mutation of cardiac troponin T on the structure of thin filaments by small-angle x-ray scattering"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-09-25"},"publish_date":"2017-09-25","publish_status":"0","recid":"72460","relation_version_is_last":true,"title":["Effects of E244D mutation of cardiac troponin T on the structure of thin filaments by small-angle x-ray scattering"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:39:35.931698+00:00"}