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Secreted factor(s) mediated bystander effects between carbon-ion irradiated tumor and non-irradiated normal cells
https://repo.qst.go.jp/records/72045
https://repo.qst.go.jp/records/7204564af16c5-e62e-4ef8-8bce-d7622a5e0fd9
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-10-19 | |||||
| タイトル | ||||||
| タイトル | Secreted factor(s) mediated bystander effects between carbon-ion irradiated tumor and non-irradiated normal cells | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
鈴木, 雅雄
× 鈴木, 雅雄× 崔, 星× 鈴木 雅雄× 崔 星 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Communication between tumor and normal cells is one of the essential concerns for radiotherapy. The last year, we reported the communication of signaling events from carbon-ion irradiated tumor to non-irradiated normal cells. This year, we focused on biological effects induced in non-irradiated normal cells via secreate factor(s) to culture medium from the irradiated tumor cells. Human glioblastoma cell line (T98G) was irradiated with carbon-ion beams (LET=73keV/µm) scheduled to either a single dose (6Gy) or three-fraction doses (3x2Gy) during three consecutive days. The medium from the irradiated T98G cells was added to the flask inoculated on the normal human cells, and then the normal human cells were assayed for micronucleus formation, cell death and gene mutation. The medium transfer resulted in increased all biological effects in the case of both the single-dose and the fraction-dose irradiations. Especially the fraction-dose irradiation showed much higher in inducing micronucleus formation and mutation than the single-dose irradiation. There is clear evidence that the medium from the irradiated tumor cells enable to induce damage in the neighboring non-irradiated normal cells via secreted factor(s) mediated bystander effect. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第75回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2016-10-08 | |||||
| 日付タイプ | Issued | |||||
