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Carbon Ion Beam Combined With Chemotherapy Destroys Pancreatic Cancer Stem Cells
https://repo.qst.go.jp/records/71975
https://repo.qst.go.jp/records/719755d9da506-f0d9-44c7-901c-a66a3e9444f2
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-08-08 | |||||
| タイトル | ||||||
| タイトル | Carbon Ion Beam Combined With Chemotherapy Destroys Pancreatic Cancer Stem Cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
崔, 星
× 崔, 星× 崔 星 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In this study we examined carbon ion beam alone or in combination with chemotherapy (TS-1 or 5FU, or gemcitabine) on putative pancreatic cancer stem cell (CSC) in vitro and in vivo. We found that the number of colony and spheroid formed from CSCs (CD44+/ESA+) after carbon ion beam was significantly reduced compared to that of X-ray, and it was extremely suppressed when combined with gemcitabine or 5-FU. The relative biological effectiveness (RBE) values for the carbon ion beam relative to X-ray at the D10 levels for CSCs were 2.23-2.66. Not only the number but also the size of gammaH2AX foci in CSCs were lager 24 h after carbon ion beam combined with 5-FU or gemcitabine compared to carbon ion beam alone or X-ray combined with 5-FU or gemcitabine. In vivo xenograft tumor control analysis showed that the tumors were not completely controlled even treated with 60 Gy of X-ray, but it was effectively destroyed with 25 Gy of carbon ion beam combined with 50 mg/kg gemcitabine or 10mg/kg TS-1. In conclusion, carbon ion beam combined with gemcitabine or TS-1 (or 5-FU) has superior potential to kill pancreatic CSCs via unrepairable clustered DSB, and multiple cell death pathways. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第47回日本膵臓学会大会(JPS),第20回国際膵臓学会(IAP),第6回アジアオセアニア膵臓学会(AOPA)合同学会 | |||||
| 発表年月日 | ||||||
| 日付 | 2016-08-06 | |||||
| 日付タイプ | Issued | |||||
