{"created":"2023-05-15T14:52:43.032102+00:00","id":71975,"links":{},"metadata":{"_buckets":{"deposit":"9065037d-3bfa-4a09-993b-91a64599cbb3"},"_deposit":{"created_by":1,"id":"71975","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71975"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071975","sets":["10:28"]},"author_link":["708912","708911"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2016-08-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this study we examined carbon ion beam alone or in combination with chemotherapy (TS-1 or 5FU, or gemcitabine)  on putative pancreatic cancer stem cell (CSC) in vitro and in vivo. We found that the number of colony and spheroid formed from CSCs (CD44+/ESA+) after carbon ion beam was significantly reduced compared to that of X-ray, and it was extremely suppressed when combined with gemcitabine or 5-FU. The relative biological effectiveness (RBE) values for the carbon ion beam relative to X-ray at the D10 levels for CSCs were 2.23-2.66. Not only the number but also the size of gammaH2AX foci in CSCs were lager 24 h after carbon ion beam combined with 5-FU or gemcitabine compared to carbon ion beam alone or X-ray combined with 5-FU or gemcitabine. In vivo xenograft tumor control analysis showed that the tumors were not completely controlled even treated with 60 Gy of X-ray, but it was effectively destroyed with 25 Gy of carbon ion beam combined with 50 mg/kg gemcitabine or 10mg/kg TS-1. In conclusion, carbon ion beam combined with gemcitabine or TS-1 (or 5-FU) has superior potential to kill pancreatic CSCs via unrepairable clustered DSB, and multiple cell death pathways.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第47回日本膵臓学会大会(JPS),第20回国際膵臓学会(IAP),第6回アジアオセアニア膵臓学会(AOPA)合同学会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"崔, 星"}],"nameIdentifiers":[{"nameIdentifier":"708911","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"崔 星","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"708912","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Carbon Ion Beam Combined With Chemotherapy Destroys Pancreatic Cancer Stem Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Carbon Ion Beam Combined With Chemotherapy Destroys Pancreatic Cancer Stem Cells"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-08"},"publish_date":"2016-08-08","publish_status":"0","recid":"71975","relation_version_is_last":true,"title":["Carbon Ion Beam Combined With Chemotherapy Destroys Pancreatic Cancer Stem Cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:45:13.969113+00:00"}