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The neural and molecular mechanisms associated with unreality feeling.
https://repo.qst.go.jp/records/71796
https://repo.qst.go.jp/records/7179679b06bc4-0c9e-444e-b40a-cc5c1c04ed03
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-18 | |||||
| タイトル | ||||||
| タイトル | The neural and molecular mechanisms associated with unreality feeling. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
横川, 啓太
× 横川, 啓太× 伊藤, 岳人× 須原, 哲也× 山田, 真希子× 横川 啓太× 伊藤 岳人× 須原 哲也× 山田 真希子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | [Background] Experience of unreality toward the external world is a characteristic of depersonalization disorder. Although depersonalization symptoms are observed in various psychiatric disorders, the underlying neural and molecular mechanisms are not well understood. The current study employed a multimodal neuroimaging strategy to explore the relationship between unreality-related neural activity, assessed using fMRI and striatal D2 receptor availability, assessed using [11C]raclopride PET with 14 healthy male subjects (23.4 ± 4.3 years old ). [Methods] Subjects rated how much visual objects looked real/unreal using a visual analog scale in the chromatic adaptation task inside an fMRI scanner. Stimuli are composed of 3 saturation levels: high, medium, low. We compared brain activities of medium chromatic object followed by high versus low. The task was performed four blocks (25 trials / brock). For evaluation of striatal D2 receptors, a bolus of 228.4 ± 8.1 MBq of [11C]raclopride with high specific radioactivity (158.4 ± 53.5 GBq/umol) was injected. Dynamic scans were performed for 60 minutes for [11C]raclopride immediately after the injection. [Results and conclusion] We observed a significant relationship wherein greater striatal D2 receptor availability was associated with greater unreality-related activities in occipital and dorsolateral prefrontal regions. Our results indicate that unreality feeling is strongly associated with an interrelationship between fronto-occipital activities and striatal dopaminergic neurotransmission. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第38回日本神経科学大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2015-07-28 | |||||
| 日付タイプ | Issued | |||||
