{"created":"2023-05-15T14:52:35.191150+00:00","id":71796,"links":{},"metadata":{"_buckets":{"deposit":"d19636f8-4698-44df-abee-c18ad19d3add"},"_deposit":{"created_by":1,"id":"71796","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71796"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071796","sets":["10:28"]},"author_link":["706703","706705","706707","706708","706706","706701","706704","706702"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-07-28","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[Background] Experience of unreality toward the external world is a characteristic of depersonalization disorder. Although depersonalization symptoms are observed in various psychiatric disorders, the underlying neural and molecular mechanisms are not well understood. The current study employed a multimodal neuroimaging strategy to explore the relationship between unreality-related neural activity, assessed using fMRI and striatal D2 receptor availability, assessed using [11C]raclopride PET with 14 healthy male subjects (23.4 ± 4.3 years old ). \n[Methods] Subjects rated how much visual objects looked real/unreal using a visual analog scale in the chromatic adaptation task inside an fMRI scanner. Stimuli are composed of 3 saturation levels: high, medium, low. We compared brain activities of medium chromatic object followed by high versus low. The task was performed four blocks (25 trials / brock). For evaluation of striatal D2 receptors, a bolus of 228.4 ± 8.1 MBq of [11C]raclopride with high specific radioactivity (158.4 ± 53.5 GBq/umol) was injected. Dynamic scans were performed for 60 minutes for [11C]raclopride immediately after the injection. \n[Results and conclusion] We observed a significant relationship wherein greater striatal D2 receptor availability was associated with greater unreality-related activities in occipital and dorsolateral prefrontal regions. Our results indicate that unreality feeling is strongly associated with an interrelationship between fronto-occipital activities and striatal dopaminergic neurotransmission.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第38回日本神経科学大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"横川, 啓太"}],"nameIdentifiers":[{"nameIdentifier":"706701","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 岳人"}],"nameIdentifiers":[{"nameIdentifier":"706702","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"706703","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 真希子"}],"nameIdentifiers":[{"nameIdentifier":"706704","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横川 啓太","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"706705","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 岳人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"706706","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"706707","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 真希子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"706708","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"The neural and molecular mechanisms associated with unreality feeling.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The neural and molecular mechanisms associated with unreality feeling."}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-08-18"},"publish_date":"2015-08-18","publish_status":"0","recid":"71796","relation_version_is_last":true,"title":["The neural and molecular mechanisms associated with unreality feeling."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:47:18.942182+00:00"}