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Analysis of Underlying Mechanisms for Combination Therapy of Carbon-ion Irradiation and Dendritic Cell Immunotherapy
https://repo.qst.go.jp/records/71666
https://repo.qst.go.jp/records/71666abdda0d1-840f-4e4b-8a18-8f122340300f
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-05-31 | |||||
| タイトル | ||||||
| タイトル | Analysis of Underlying Mechanisms for Combination Therapy of Carbon-ion Irradiation and Dendritic Cell Immunotherapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ma, Liqiu
× Ma, Liqiu× Ando, Ken× Irie, Daisuke× Sato, Katsutoshi× Imai, Takashi× Shimokawa, Takashi× 馬 立秋× 安藤 謙× 入江 大介× 佐藤 克俊× 今井 高志× 下川 卓志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Carbon-ion (C-ion) radiotherapy (RT) is an advanced effective RT in tumors that are difficult to be cured by conventional RT due to its biological properties and excellent dose distribution. Although C-ion radiotherapy has shown good outcomes, metastasis control is an important matter as with any type of cancer treatment. There are some reports that C-ion irradiation tends to suppress metastasis or relevant abilities at in vitro and in vivo models. However, the underlying mechanisms are still not clearly understood. To improve C-ion RT, we aimed to find an optimal combination therapy for C-ion radiotherapy to prevent distant metastasis. In this study, we evaluated dendritic cells (DCs) immunotherapy, as a partner for C-ion radiotherapy. We used mouse allograft models using four mouse cancer cell lines (NR-S1, LM8, LLC and Colon26) and three mouse strains (C3H/He, C57BL/6J and BALB/c) under conditions that there were no significant effects on growth of transplanted tumor by the C-ion treatments. In NR-S1 or LM8 grafted C3H/He and LLC grafted C57BL/6J models, the number of lung metastasis was significantly decreased by the combined therapy. However, Colon26 grafted BALB/c model did not show the enhancement of metastasis inhibition by the combination treatment. To clarify the mechanisms behind the model difference, we investigated further by comparing LLC grafted C57BL/6J and Colon26 grafted BALB/c models. Dual legs grafted-one leg C-ion irradiation assay clearly demonstrated that local C-ion treatment was able to repress lung metastasis from distal non-irradiated tumor in both models. In contrast, in vitro co-culture assay indicated that C-ion irradiated Colon26 cells were not able to activate iDCs into the mature DCs, whereas LLC cells could. These results indicate that C-ion local irradiation by itself has strong ability to activate metastasis inhibition in the whole body, and genetic background or/and cancer cell type may have potent impact on the efficiency of the combination therapy. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 15th International Congress of Radiation Research (ICRR 2015) | |||||
| 発表年月日 | ||||||
| 日付 | 2015-05-28 | |||||
| 日付タイプ | Issued | |||||
