{"created":"2023-05-15T14:52:29.448357+00:00","id":71666,"links":{},"metadata":{"_buckets":{"deposit":"616805d0-2be8-4970-8358-cf927597d050"},"_deposit":{"created_by":1,"id":"71666","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71666"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071666","sets":["10:28"]},"author_link":["705155","705164","705162","705165","705158","705160","705161","705166","705159","705157","705156","705163"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-05-28","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Carbon-ion (C-ion) radiotherapy (RT) is an advanced effective RT in tumors that are difficult to be cured by conventional RT due to its biological properties and excellent dose distribution.  Although C-ion radiotherapy has shown good outcomes, metastasis control is an important matter as with any type of cancer treatment. There are some reports that C-ion irradiation tends to suppress metastasis or relevant abilities at in vitro and in vivo models. However, the underlying mechanisms are still not clearly understood. \n To improve C-ion RT, we aimed to find an optimal combination therapy for C-ion radiotherapy to prevent distant metastasis. In this study, we evaluated dendritic cells (DCs) immunotherapy, as a partner for C-ion radiotherapy. We used mouse allograft models using four mouse cancer cell lines (NR-S1, LM8, LLC and Colon26) and three mouse strains (C3H/He, C57BL/6J and BALB/c) under conditions that there were no significant effects on growth of transplanted tumor by the C-ion treatments. In NR-S1 or LM8 grafted C3H/He and LLC grafted C57BL/6J models, the number of lung metastasis was significantly decreased by the combined therapy. However, Colon26 grafted BALB/c model did not show the enhancement of metastasis inhibition by the combination treatment. To clarify the mechanisms behind the model difference, we investigated further by comparing LLC grafted C57BL/6J and Colon26 grafted BALB/c models. Dual legs grafted-one leg C-ion irradiation assay clearly demonstrated that local C-ion treatment was able to repress lung metastasis from distal non-irradiated tumor in both models. In contrast, in vitro co-culture assay indicated that C-ion irradiated Colon26 cells were not able to activate iDCs into the mature DCs, whereas LLC cells could. These results indicate that C-ion local irradiation by itself has strong ability to activate metastasis inhibition in the whole body, and genetic background or/and cancer cell type may have potent impact on the efficiency of the combination therapy.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"15th International Congress of Radiation Research (ICRR 2015)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ma, Liqiu"}],"nameIdentifiers":[{"nameIdentifier":"705155","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ando, Ken"}],"nameIdentifiers":[{"nameIdentifier":"705156","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Irie, Daisuke"}],"nameIdentifiers":[{"nameIdentifier":"705157","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Katsutoshi"}],"nameIdentifiers":[{"nameIdentifier":"705158","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"705159","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimokawa, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"705160","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"馬 立秋","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705161","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 謙","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705162","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 大介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705163","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤 克俊","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705164","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705165","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下川 卓志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"705166","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Analysis of Underlying Mechanisms for Combination Therapy of Carbon-ion Irradiation and Dendritic Cell Immunotherapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Analysis of Underlying Mechanisms for Combination Therapy of Carbon-ion Irradiation and Dendritic Cell Immunotherapy"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-31"},"publish_date":"2015-05-31","publish_status":"0","recid":"71666","relation_version_is_last":true,"title":["Analysis of Underlying Mechanisms for Combination Therapy of Carbon-ion Irradiation and Dendritic Cell Immunotherapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:48:43.925230+00:00"}