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SPECT imaging for amyloid plaques with a novel radioiodinated ligand in Alzheimer's disease model

https://repo.qst.go.jp/records/71627
https://repo.qst.go.jp/records/71627
6b20f8f0-f316-419c-b274-42f40892b416
Item type 会議発表用資料 / Presentation(1)
公開日 2015-04-20
タイトル
タイトル SPECT imaging for amyloid plaques with a novel radioiodinated ligand in Alzheimer's disease model
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Ji, Bin

× Ji, Bin

WEKO 704675

Ji, Bin

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Chen, Chun-Jen

× Chen, Chun-Jen

WEKO 704676

Chen, Chun-Jen

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Bando, Kazunori

× Bando, Kazunori

WEKO 704677

Bando, Kazunori

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Ashino, Hiroki

× Ashino, Hiroki

WEKO 704678

Ashino, Hiroki

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Shima, Keiji

× Shima, Keiji

WEKO 704679

Shima, Keiji

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Uchida, Keisuke

× Uchida, Keisuke

WEKO 704680

Uchida, Keisuke

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Fujimoto, Ousuke

× Fujimoto, Ousuke

WEKO 704681

Fujimoto, Ousuke

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Kitamura, Chiemi

× Kitamura, Chiemi

WEKO 704682

Kitamura, Chiemi

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Nakahara, Yuuto

× Nakahara, Yuuto

WEKO 704683

Nakahara, Yuuto

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Shiraishi, Hideaki

× Shiraishi, Hideaki

WEKO 704684

Shiraishi, Hideaki

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Matsushima, Satoshi

× Matsushima, Satoshi

WEKO 704685

Matsushima, Satoshi

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Zhang, Ming-Rong

× Zhang, Ming-Rong

WEKO 704686

Zhang, Ming-Rong

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Ono, Maiko

× Ono, Maiko

WEKO 704687

Ono, Maiko

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Tokunaga, Masaki

× Tokunaga, Masaki

WEKO 704688

Tokunaga, Masaki

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Minamihisamatsu, Takeharu

× Minamihisamatsu, Takeharu

WEKO 704689

Minamihisamatsu, Takeharu

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Suhara, Tetsuya

× Suhara, Tetsuya

WEKO 704690

Suhara, Tetsuya

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Higuchi, Makoto

× Higuchi, Makoto

WEKO 704691

Higuchi, Makoto

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Yamada, Kazutaka

× Yamada, Kazutaka

WEKO 704692

Yamada, Kazutaka

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季 斌

× 季 斌

WEKO 704693

en 季 斌

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張 明栄

× 張 明栄

WEKO 704694

en 張 明栄

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小野 麻衣子

× 小野 麻衣子

WEKO 704695

en 小野 麻衣子

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徳永 正希

× 徳永 正希

WEKO 704696

en 徳永 正希

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南久松 丈晴

× 南久松 丈晴

WEKO 704697

en 南久松 丈晴

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須原 哲也

× 須原 哲也

WEKO 704698

en 須原 哲也

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樋口 真人

× 樋口 真人

WEKO 704699

en 樋口 真人

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抄録
内容記述タイプ Abstract
内容記述 Background: Non-invasive determination for amyloid- peptide (A) deposition has important significance for early diagnosis and medical intervention to Alzheimer’s disease (AD). Until now, however, little single photon emission computed tomography (SPECT) imaging agents have successfully detected A deposition in the living brains. In the present study, we have developed a serial of imidazopyridine derivatives for SPECT imaging.
\nMethod: Five compounds with imidazopyridine structure were synthesized and the affinity to human Ab fibrils were evaluated with IC50 for binding of [125I]IMPY. The compounds with high affinity were selected for further development. The detectability of Ab deposition was investigated by in-vitro autoradiography and in-vivo SPECT imaging in AD model mouse (Tg2576), and compared with positron emission tomography (PET) imaging with [11C]PiB.

Results: Two of newly developed compounds, compound 1 and 5, showed higher affinity to synthetic human A1-40 fibrils than well-known amyloid imaging agent IMPY. Further metabolite analysis has detected brain-permeable radioactive metabolites of 125I-labeled compound 1and IMPY, a well-known ligand for SPECT imaging, while no radioactive metabolite from 125I-labeled compound 5([125I]compound 5) was detectable. In vitro autoradiography has clearly demonstrated that there was overt specific binding of [125I] compound 5 in temporal cortex region of AD enriched with A plaques. Moreover, ex vivo autoradiographic analysis showed that measurement with [125I] compound 5 has higher sensibility for detecting A accumulation than with [125I]IMPY, in Tg2576 mouse. SPECT imaging with [123I] compound 5 has also successfully detected A deposition in the living aged Tg2576 mice, and furthermore showed strong correlation in quantitative analysis for A plaques detection with positron emission tomography (PET) imaging with [11C]PiB, implying that [123I] compound 5 has detectability at least equivalent to [11C]PiB for A deposition.
\nConclusions: [123I] compound 5 has demonstrated high potential as SPECT ligand for further clinical application.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 AAIC2014
発表年月日
日付 2014-07-13
日付タイプ Issued
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