{"created":"2023-05-15T14:52:27.690967+00:00","id":71627,"links":{},"metadata":{"_buckets":{"deposit":"03fd9b6a-e320-4c5d-9727-78174f5f72cf"},"_deposit":{"created_by":1,"id":"71627","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71627"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071627","sets":["10:28"]},"author_link":["704695","704678","704692","704676","704697","704687","704693","704685","704675","704681","704698","704689","704694","704688","704686","704683","704691","704680","704699","704696","704677","704679","704682","704684","704690"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-07-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Non-invasive determination for amyloid- peptide (A) deposition has important significance for early diagnosis and medical intervention to Alzheimer’s disease (AD). Until now, however, little single photon emission computed tomography (SPECT) imaging agents have successfully detected A deposition in the living brains. In the present study, we have developed a serial of imidazopyridine derivatives for SPECT imaging.\n\\nMethod: Five compounds with imidazopyridine structure were synthesized and the affinity to human Ab fibrils were evaluated with IC50 for binding of [125I]IMPY. The compounds with high affinity were selected for further development. The detectability of Ab deposition was investigated by in-vitro autoradiography and in-vivo SPECT imaging in AD model mouse (Tg2576), and compared with positron emission tomography (PET) imaging with [11C]PiB. \n \nResults: Two of newly developed compounds, compound 1 and 5, showed higher affinity to synthetic human A1-40 fibrils than well-known amyloid imaging agent IMPY. Further metabolite analysis has detected brain-permeable radioactive metabolites of 125I-labeled compound 1and IMPY, a well-known ligand for SPECT imaging, while no radioactive metabolite from 125I-labeled compound 5([125I]compound 5) was detectable. In vitro autoradiography has clearly demonstrated that there was overt specific binding of [125I] compound 5 in temporal cortex region of AD enriched with A plaques. Moreover, ex vivo autoradiographic analysis showed that measurement with [125I] compound 5 has higher sensibility for detecting A accumulation than with [125I]IMPY, in Tg2576 mouse. SPECT imaging with [123I] compound 5 has also successfully detected A deposition in the living aged Tg2576 mice, and furthermore showed strong correlation in quantitative analysis for A plaques detection with positron emission tomography (PET) imaging with [11C]PiB, implying that [123I] compound 5 has detectability at least equivalent to [11C]PiB for A deposition. \n\\nConclusions: [123I] compound 5 has demonstrated high potential as SPECT ligand for further clinical application.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"AAIC2014","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ji, Bin"}],"nameIdentifiers":[{"nameIdentifier":"704675","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chen, Chun-Jen"}],"nameIdentifiers":[{"nameIdentifier":"704676","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bando, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"704677","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ashino, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"704678","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shima, Keiji"}],"nameIdentifiers":[{"nameIdentifier":"704679","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uchida, Keisuke"}],"nameIdentifiers":[{"nameIdentifier":"704680","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujimoto, Ousuke"}],"nameIdentifiers":[{"nameIdentifier":"704681","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitamura, Chiemi"}],"nameIdentifiers":[{"nameIdentifier":"704682","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakahara, Yuuto"}],"nameIdentifiers":[{"nameIdentifier":"704683","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shiraishi, Hideaki"}],"nameIdentifiers":[{"nameIdentifier":"704684","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsushima, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"704685","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"704686","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Maiko"}],"nameIdentifiers":[{"nameIdentifier":"704687","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tokunaga, Masaki"}],"nameIdentifiers":[{"nameIdentifier":"704688","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minamihisamatsu, Takeharu"}],"nameIdentifiers":[{"nameIdentifier":"704689","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"704690","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"704691","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Kazutaka"}],"nameIdentifiers":[{"nameIdentifier":"704692","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"季 斌","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704693","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704694","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小野 麻衣子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704695","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"徳永 正希","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704696","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"南久松 丈晴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704697","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704698","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"704699","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"SPECT imaging for amyloid plaques with a novel radioiodinated ligand in Alzheimer's disease model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"SPECT imaging for amyloid plaques with a novel radioiodinated ligand in Alzheimer's disease model"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-04-20"},"publish_date":"2015-04-20","publish_status":"0","recid":"71627","relation_version_is_last":true,"title":["SPECT imaging for amyloid plaques with a novel radioiodinated ligand in Alzheimer's disease model"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:49:08.506123+00:00"}