{"_buckets": {"deposit": "1cc26781-f061-4f5b-b4a3-cf450ce19833"}, "_deposit": {"created_by": 1, "id": "71606", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "71606"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00071606", "sets": ["28"]}, "author_link": ["704285", "704274", "704286", "704287", "704289", "704276", "704290", "704288", "704273", "704280", "704275", "704271", "704283", "704277", "704282", "704281", "704270", "704284", "704278", "704272", "704279"], "item_10005_date_7": {"attribute_name": "発表年月日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2013-05-23", "subitem_date_issued_type": "Issued"}]}, "item_10005_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objectives: To clarify whether imaging for cyclooxygenase-2(COX-2) is potential for monitoring pathological advance in ischemic diseases, and labeled COX-2 selective inhibitors are available as positron emission tomography (PET) tracers for COX-2 imaging. \nMethods: We have investigated the expression of COX-2 in normal and ischemic mouse brain with an original anti-COX-2 antibody with high specificity against murine COX-2 molecule and performed in-vivo living imaging and in-vitro autoradiographic analysis with two radio-synthesized first-generation COX-2 selective inhibitors ([11C]celecoxib) and [11C]rofecoxib), in normal and ischemic mouse brains \nResults: The immunohistochemical analysis showed the expression of COX-2 was exclusively localized in neurons with the most abundant amount in cerebellum and brainstem in normal mouse brain, and such expression was detectable by in-vitro autoradiographic analysis with [11C]rofecoxib, not [11C]celecoxib. In-vivo imaging with both of these two PET tracers failed to detect COX-2 expression despite their excellent brain permeability. The hypoperfusion-induced ischemia caused overt necrotic neuron death accompanied with gliosis in hippocampus, where significant induction of COX-2 was detected exclusively in injured neuron soma and synapse-like structure. The binding of [11C]rofecoxib was also increased in injured hippocampus compared to uninjured corresponding region.\nConclusions: COX-2 is suitable biomarker for monitoring progressive ischemic injury and developing PET tracers for COX-2 imaging with COX-2 selective inhibitors is feasible for this purpose, although in-vivo living imaging requires further development of PET tracer with higher affinity than [11C]celecoxib and [11C]rofecoxib.", "subitem_description_type": "Abstract"}]}, "item_10005_description_6": {"attribute_name": "会議概要（会議名, 開催地, 会期, 主催者等）", "attribute_value_mlt": [{"subitem_description": "BRAIN\u002713 and BRAINPET\u002713", "subitem_description_type": "Other"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ji, Bin"}], "nameIdentifiers": [{"nameIdentifier": "704270", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Ming-Rong"}], "nameIdentifiers": [{"nameIdentifier": "704271", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kaneko, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "704272", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kumata, Katsushi"}], "nameIdentifiers": [{"nameIdentifier": "704273", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Seki, Chie"}], "nameIdentifiers": [{"nameIdentifier": "704274", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ono, Maiko"}], "nameIdentifiers": [{"nameIdentifier": "704275", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tokunaga, Masaki"}], "nameIdentifiers": [{"nameIdentifier": "704276", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Minamihisamatsu, Takeharu"}], "nameIdentifiers": [{"nameIdentifier": "704277", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "704278", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suhara, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "704279", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "et.al"}], "nameIdentifiers": [{"nameIdentifier": "704280", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "季 斌", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704281", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "張 明栄", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704282", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "金子 博之", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704283", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "熊田 勝志", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704284", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "関 千江", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704285", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小野 麻衣子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704286", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "徳永 正希", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704287", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "南久松 丈晴", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704288", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "樋口 真人", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704289", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "須原 哲也", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "704290", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "conference object", "resourceuri": "http://purl.org/coar/resource_type/c_c94f"}]}, "item_title": "The Induction of Cycloloxygenase-2(COX-2) Expression Responding to Ischemic Neuronal Injury and PET Imaging with Two Radio-labeled First-generation COX-2 Selective Inhibitors", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The Induction of Cycloloxygenase-2(COX-2) Expression Responding to Ischemic Neuronal Injury and PET Imaging with Two Radio-labeled First-generation COX-2 Selective Inhibitors"}]}, "item_type_id": "10005", "owner": "1", "path": ["28"], "permalink_uri": "https://repo.qst.go.jp/records/71606", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-04-20"}, "publish_date": "2015-04-20", "publish_status": "0", "recid": "71606", "relation": {}, "relation_version_is_last": true, "title": ["The Induction of Cycloloxygenase-2(COX-2) Expression Responding to Ischemic Neuronal Injury and PET Imaging with Two Radio-labeled First-generation COX-2 Selective Inhibitors"], "weko_shared_id": -1}