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The Induction of Cycloloxygenase-2(COX-2) Expression Responding to Ischemic Neuronal Injury and PET Imaging with Two Radio-labeled First-generation COX-2 Selective Inhibitors

https://repo.qst.go.jp/records/71606
https://repo.qst.go.jp/records/71606
2b813759-0a0b-4431-8e7d-1e6fca3134ae
Item type 会議発表用資料 / Presentation(1)
公開日 2015-04-20
タイトル
タイトル The Induction of Cycloloxygenase-2(COX-2) Expression Responding to Ischemic Neuronal Injury and PET Imaging with Two Radio-labeled First-generation COX-2 Selective Inhibitors
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Ji, Bin

× Ji, Bin

WEKO 704270

Ji, Bin

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Zhang, Ming-Rong

× Zhang, Ming-Rong

WEKO 704271

Zhang, Ming-Rong

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Kaneko, Hiroyuki

× Kaneko, Hiroyuki

WEKO 704272

Kaneko, Hiroyuki

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Kumata, Katsushi

× Kumata, Katsushi

WEKO 704273

Kumata, Katsushi

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Seki, Chie

× Seki, Chie

WEKO 704274

Seki, Chie

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Ono, Maiko

× Ono, Maiko

WEKO 704275

Ono, Maiko

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Tokunaga, Masaki

× Tokunaga, Masaki

WEKO 704276

Tokunaga, Masaki

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Minamihisamatsu, Takeharu

× Minamihisamatsu, Takeharu

WEKO 704277

Minamihisamatsu, Takeharu

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Higuchi, Makoto

× Higuchi, Makoto

WEKO 704278

Higuchi, Makoto

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Suhara, Tetsuya

× Suhara, Tetsuya

WEKO 704279

Suhara, Tetsuya

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et.al

× et.al

WEKO 704280

et.al

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季 斌

× 季 斌

WEKO 704281

en 季 斌

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張 明栄

× 張 明栄

WEKO 704282

en 張 明栄

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金子 博之

× 金子 博之

WEKO 704283

en 金子 博之

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熊田 勝志

× 熊田 勝志

WEKO 704284

en 熊田 勝志

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関 千江

× 関 千江

WEKO 704285

en 関 千江

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小野 麻衣子

× 小野 麻衣子

WEKO 704286

en 小野 麻衣子

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徳永 正希

× 徳永 正希

WEKO 704287

en 徳永 正希

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南久松 丈晴

× 南久松 丈晴

WEKO 704288

en 南久松 丈晴

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樋口 真人

× 樋口 真人

WEKO 704289

en 樋口 真人

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須原 哲也

× 須原 哲也

WEKO 704290

en 須原 哲也

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抄録
内容記述タイプ Abstract
内容記述 Objectives: To clarify whether imaging for cyclooxygenase-2(COX-2) is potential for monitoring pathological advance in ischemic diseases, and labeled COX-2 selective inhibitors are available as positron emission tomography (PET) tracers for COX-2 imaging.
Methods: We have investigated the expression of COX-2 in normal and ischemic mouse brain with an original anti-COX-2 antibody with high specificity against murine COX-2 molecule and performed in-vivo living imaging and in-vitro autoradiographic analysis with two radio-synthesized first-generation COX-2 selective inhibitors ([11C]celecoxib) and [11C]rofecoxib), in normal and ischemic mouse brains
Results: The immunohistochemical analysis showed the expression of COX-2 was exclusively localized in neurons with the most abundant amount in cerebellum and brainstem in normal mouse brain, and such expression was detectable by in-vitro autoradiographic analysis with [11C]rofecoxib, not [11C]celecoxib. In-vivo imaging with both of these two PET tracers failed to detect COX-2 expression despite their excellent brain permeability. The hypoperfusion-induced ischemia caused overt necrotic neuron death accompanied with gliosis in hippocampus, where significant induction of COX-2 was detected exclusively in injured neuron soma and synapse-like structure. The binding of [11C]rofecoxib was also increased in injured hippocampus compared to uninjured corresponding region.
Conclusions: COX-2 is suitable biomarker for monitoring progressive ischemic injury and developing PET tracers for COX-2 imaging with COX-2 selective inhibitors is feasible for this purpose, although in-vivo living imaging requires further development of PET tracer with higher affinity than [11C]celecoxib and [11C]rofecoxib.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 BRAIN'13 and BRAINPET'13
発表年月日
日付 2013-05-23
日付タイプ Issued
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