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Clinical evaluation of FAZA and FDG PET/CT for advanced lung cancer patients.
https://repo.qst.go.jp/records/71474
https://repo.qst.go.jp/records/71474eadb3239-cbb2-4dbe-ab9b-1b5f085f1254
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-06-20 | |||||
| タイトル | ||||||
| タイトル | Clinical evaluation of FAZA and FDG PET/CT for advanced lung cancer patients. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Saga, Tsuneo
× Saga, Tsuneo× Inubushi, Masayuki× Koizumi, Mitsuru× Yoshikawa, Kyosan× Zhang, Ming-Rong× Horiike, Atsushi× Kudo, Keita× Ohyanagi, Fumiyoshi× Nishio, Makoto× 佐賀 恒夫× 犬伏 正幸× 小泉 満× 吉川 京燦× 張 明栄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: The aim of the present study was to evaluate the clinical value of PET/CT with FAZA, a PET probe for tumor hypoxia, for advanced lung cancer patients, in comparison to FDG-PET/CT. \nMethods: Thirty four patients with non-small cell lung cancer (stage III and IV) received PET/CT with FAZA and FDG. After treatment, patients were followed to evaluate the treatment response and survival. Overall-, progression-free survival, local control and control of LN metastases were compared with uptake parameters of FAZA (tumor-muscle ratio at 2h (T/M)) and FDG (SUVmax at 1h (SUV)). Study protocol was approved by the institutional review board, and informed consent was obtained from all patients. \nResults: There was a weak correlation between FAZA T/M and FDG SUV of primary lesion, but intra-tumoral distribution patterns were not identical. Stage IV patients tended to show worse overall- and progression-free survival than stage III patients (p=0.122 and 0.124, respectively). Although not statistically significant, mean FAZA T/M of primary lesion tended to be higher in non-survivors and in patients with disease progression, whereas such tendency was not observed for mean FDG SUV. Furthermore, patients with FAZA T/M > 2.245 showed significantly worse progression-free survival (p=0.028). Patients who developed local recurrence showed significantly higher mean FAZA T/M (p=0.009) of primary lesion than who did not. In contrast, significantly higher mean FDG SUV of LN metastasis was observed in patients who developed recurrence in LN metastasis (p = 0.043). Mean FAZA T/M of LN metastasis was also higher in patients who developed LN recurrence (p = 0.070). \nConclusion: PET/CT with FAZA may have a potential for the prediction of disease control and survival of advanced lung cancer patients. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | SNMMI 2014 Annual meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2014-06-09 | |||||
| 日付タイプ | Issued | |||||
