@misc{oai:repo.qst.go.jp:00071474,
 author = {Saga, Tsuneo and Inubushi, Masayuki and Koizumi, Mitsuru and Yoshikawa, Kyosan and Zhang, Ming-Rong and Horiike, Atsushi and Kudo, Keita and Ohyanagi, Fumiyoshi and Nishio, Makoto and 佐賀 恒夫 and 犬伏 正幸 and 小泉 満 and 吉川 京燦 and 張 明栄},
 month = {Jun},
 note = {Objectives: The aim of the present study was to evaluate the clinical value of PET/CT with FAZA, a PET probe for tumor hypoxia, for advanced lung cancer patients, in comparison to FDG-PET/CT.
\nMethods: Thirty four patients with non-small cell lung cancer (stage III and IV) received PET/CT with FAZA and FDG. After treatment, patients were followed to evaluate the treatment response and survival. Overall-, progression-free survival, local control and control of LN metastases were compared with uptake parameters of FAZA (tumor-muscle ratio at 2h (T/M)) and FDG (SUVmax at 1h (SUV)). Study protocol was approved by the institutional review board, and informed consent was obtained from all patients.
\nResults: There was a weak correlation between FAZA T/M and FDG SUV of primary lesion, but intra-tumoral distribution patterns were not identical. Stage IV patients tended to show worse overall- and progression-free survival than stage III patients (p=0.122 and 0.124, respectively). Although not statistically significant, mean FAZA T/M of primary lesion tended to be higher in non-survivors and in patients with disease progression, whereas such tendency was not observed for mean FDG SUV. Furthermore, patients with FAZA T/M > 2.245 showed significantly worse progression-free survival (p=0.028). Patients who developed local recurrence showed significantly higher mean FAZA T/M (p=0.009) of primary lesion than who did not. In contrast, significantly higher mean FDG SUV of LN metastasis was observed in patients who developed recurrence in LN metastasis (p = 0.043). Mean FAZA T/M of LN metastasis was also higher in patients who developed LN recurrence (p = 0.070). 
\nConclusion: PET/CT with FAZA may have a potential for the prediction of disease control and survival of advanced lung cancer patients., SNMMI 2014 Annual meeting},
 title = {Clinical evaluation of FAZA and FDG PET/CT for advanced lung cancer patients.},
 year = {2014}
}