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Damaging and protective bystander cross-talk between human lung cancer and normal cells after proton microbeam irradiation.
https://repo.qst.go.jp/records/71462
https://repo.qst.go.jp/records/7146224016605-1971-4c51-8ea8-b752726ae424
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-06-02 | |||||
| タイトル | ||||||
| タイトル | Damaging and protective bystander cross-talk between human lung cancer and normal cells after proton microbeam irradiation. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Desai, Sejal
× Desai, Sejal× Kobayashi, Alisa× Konishi, Teruaki× Oikawa, Masakazu× N., Pandey Badri× 小林 亜利紗× 小西 輝昭× 及川 将一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We reports on radiation induced bystander effect with relevance to cancer radiotherapy especially investigating the bidirectional and criss-cross bystander communications between cancer and normal cells are limited. In this study employing co-culture approach, we have investigated the bystander cross-talk between A549 lung cancer and WI38 normal cells after proton-microbeam irradiation using γ-H2AX foci fluorescence as a measure of DNA double-strand breaks (DSBs). We observed that in A549-A549 co-cultures, irradiated A549 cells exert damaging effects in bystander A549 cells, which were found to be mediated through gap junctional intercellular communication (GJIC). However, in A549-WI38 co-cultures irradiated A549 did not affect bystander WI38 cells. Rather, bystander WI38 cells induced inverse protective signaling (rescue effect) in irradiated A549 cells, which was independent of GJIC. On the other hand, in response to irradiated WI38 cells neither of the bystander cells (A549 or WI38) showed significant increase in γ-H2AX foci. The observed bystander signaling between tumor and normal cells may have potential implications in therapeutic outcome of cancer radiotherapy. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第４回共用施設（PASTA&SPICE, NASBEE)共同研究成果報告会 | |||||
| 発表年月日 | ||||||
| 日付 | 2014-03-20 | |||||
| 日付タイプ | Issued | |||||
