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Roles of DNA repair and MAPK pathway in the bystander responses induced by organelle target irradiation
https://repo.qst.go.jp/records/71457
https://repo.qst.go.jp/records/71457bc5c6f76-b15f-4182-98a1-fb759331aa7b
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-05-30 | |||||
| タイトル | ||||||
| タイトル | Roles of DNA repair and MAPK pathway in the bystander responses induced by organelle target irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Dong, Chen
× Dong, Chen× Tu, Wenzhi× Konishi, Teruaki× Kobayashi, Alisa× Uchihori, Yukio× K., Hei Tom× Shao, Chunlin× 小西 輝昭× 小林 亜利紗× 内堀 幸夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Proton irradiation is one of the most important concerns in the cancer risks of space flight. Appling the advantage of microbeam irradiation, this study investigated the characteristics of nuclear irradiation and cytoplasmic irradiation induced bystander effects (RIBE) on lung cells MRC-5, especially the roles of MAPK and DNA repair. It was found that both nuclear IR and cytoplasmic IR could induce bystander DNA damage together with the generation of intracellular ROS. These RIBEs and ROS induction were eliminated by either filipin or JNK siRNA. On the other side, the role of DNA repair capacity in RIBE was also explored by co-culturing the particle irradiated CHO cells with nonirradiated population of CHO, EM-C11 (SSB repair deficient), or XR-C1 (DSB repair deficient). For both nuclear IR and cytoplasmic IR, the extra MN formation were only observed in EM-C11 and XR-C1 cells but not CHO cells. Our results disclose that cytoplasm plays a role as important as nucleus in RIBE where MAPK and DNA repair are involved. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第４回共用施設（PASTA&SPICE, NASBEE)共同研究成果報告会 | |||||
| 発表年月日 | ||||||
| 日付 | 2014-03-20 | |||||
| 日付タイプ | Issued | |||||
