@misc{oai:repo.qst.go.jp:00071457,
 author = {Dong, Chen and Tu, Wenzhi and Konishi, Teruaki and Kobayashi, Alisa and Uchihori, Yukio and K., Hei Tom and Shao, Chunlin and 小西 輝昭 and 小林 亜利紗 and 内堀 幸夫},
 month = {Mar},
 note = {Proton irradiation is one of the most important concerns in the cancer risks　of space flight. Appling the advantage of microbeam irradiation, this study investigated the characteristics of nuclear irradiation and cytoplasmic irradiation induced bystander effects (RIBE) on lung cells MRC-5, especially the roles of MAPK and DNA repair. It was found that both nuclear IR and cytoplasmic IR could induce bystander DNA damage together with the generation of intracellular ROS. These RIBEs and ROS induction were eliminated by either filipin or JNK siRNA. On the other side, the role of DNA repair capacity in RIBE was also explored by co-culturing the particle irradiated CHO cells with nonirradiated population of CHO, EM-C11 (SSB repair deficient), or XR-C1 (DSB repair deficient). For both nuclear IR and cytoplasmic IR, the extra MN formation were only observed in EM-C11 and XR-C1 cells but not CHO cells. Our results disclose that cytoplasm plays a role as important as nucleus in RIBE where MAPK and DNA repair are involved., 第４回共用施設（PASTA&SPICE, NASBEE)共同研究成果報告会},
 title = {Roles of DNA repair and MAPK pathway in the bystander responses induced by organelle target irradiation},
 year = {2014}
}