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Heterochromatin focus number correlates with X-ray and carbon ion beam resistance in cancer cells
https://repo.qst.go.jp/records/71311
https://repo.qst.go.jp/records/7131172e015f5-b73e-438d-81fd-a69b5fd1e535
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-10-24 | |||||
| タイトル | ||||||
| タイトル | Heterochromatin focus number correlates with X-ray and carbon ion beam resistance in cancer cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sato, Katsutoshi
× Sato, Katsutoshi× Imai, Takashi× Shimokawa, Takashi× 佐藤 克俊× 今井 高志× 下川 卓志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The aim of this study is to establish X-ray resistant cell lines by repeated X-ray irradiation, and to assess the characteristics of these cells to see whether they are also resistant to carbon ion beams (C-ion). The mouse adenocarcinoma cell line NRS1 was irradiated 6 times with 10Gy of X-ray. After 60 Gy of X-ray irradiation, X-ray resistant cancer cells, named NRS1-X60, as well as 10 subclones, which were selected from NRS1-X60 cells, were established. Surprisingly, NRS1-X60 cells and all subclones were also resistant to 290 MeV/n of C-ion irradiation in comparison with NRS1. Additionally, heterochromatin focus numbers were significantly increased in the X-ray/C-ion resistant subclones and NRS1-X60 cells, and they strongly correlated with both X-ray and C-ion resistance. Moreover, the focus number of gamma-H2AX remaining after X-ray or C-ion irradiation was lower in NRS1-X60 and the X-ray/C-ion resistant subclones compared to that of NRS1 cells. Our results showed that the repeated X-ray irradiations can generate not only X-ray resistance but also C-ion resistance, and the increase of heterochromatin focus number might be a marker of radioresistance. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 72nd Annual Meeting of the Japanese Cancer Association | |||||
| 発表年月日 | ||||||
| 日付 | 2013-10-05 | |||||
| 日付タイプ | Issued | |||||
