{"created":"2023-05-15T14:52:13.756441+00:00","id":71311,"links":{},"metadata":{"_buckets":{"deposit":"2be59965-c30d-4987-9ece-f2ffa4fd63d5"},"_deposit":{"created_by":1,"id":"71311","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71311"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071311","sets":["10:28"]},"author_link":["701080","701082","701079","701078","701081","701083"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-10-05","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of this study is to establish X-ray resistant cell lines by repeated X-ray irradiation, and to assess the characteristics of these cells to see whether they are also resistant to carbon ion beams (C-ion). The mouse adenocarcinoma cell line NRS1 was irradiated 6 times with 10Gy of X-ray. After 60 Gy of X-ray irradiation, X-ray resistant cancer cells, named NRS1-X60, as well as 10 subclones, which were selected from NRS1-X60 cells, were established. Surprisingly, NRS1-X60 cells and all subclones were also resistant to 290 MeV/n of C-ion irradiation in comparison with NRS1. Additionally, heterochromatin focus numbers were significantly increased in the X-ray/C-ion resistant subclones and NRS1-X60 cells, and they strongly correlated with both X-ray and C-ion resistance. Moreover, the focus number of gamma-H2AX remaining after X-ray or C-ion irradiation was lower in NRS1-X60 and the X-ray/C-ion resistant subclones compared to that of NRS1 cells. Our results showed that the repeated X-ray irradiations can generate not only X-ray resistance but also C-ion resistance, and the increase of heterochromatin focus number might be a marker of radioresistance.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"The 72nd Annual Meeting of the Japanese Cancer Association","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sato, Katsutoshi"}],"nameIdentifiers":[{"nameIdentifier":"701078","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"701079","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimokawa, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"701080","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤 克俊","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701081","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701082","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下川 卓志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"701083","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Heterochromatin focus number correlates with X-ray and carbon ion beam resistance in cancer cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Heterochromatin focus number correlates with X-ray and carbon ion beam resistance in cancer cells"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-10-24"},"publish_date":"2013-10-24","publish_status":"0","recid":"71311","relation_version_is_last":true,"title":["Heterochromatin focus number correlates with X-ray and carbon ion beam resistance in cancer cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:52:43.637039+00:00"}