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Modification of radiation-induced adaptive response in mice (Yonezawa Effect) by diet restriction
https://repo.qst.go.jp/records/71309
https://repo.qst.go.jp/records/71309537c9877-536e-414e-9196-7789635c81e5
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-10-23 | |||||
| タイトル | ||||||
| タイトル | Modification of radiation-induced adaptive response in mice (Yonezawa Effect) by diet restriction | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Bing, Wang
× Bing, Wang× Tanaka, Kaoru× Ninomiya, Yasuharu× Mori, Masahiko× Maruyama, Kouichi× Katsube, Takanori× Morimoto, Yasuko× Nenoi, Mitsuru× 王 冰× 田中 薫× 二宮 康晴× 森 雅彦× 丸山 耕一× 勝部 孝則× 森本 泰子× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation-induced adaptive response (AR) in mice (Yonezawa Effect) was a phenomenon that a priming low dose induced resistance against the bone marrow death caused by the subsequent challenge irradiation at higher doses. This mouse AR model was established using X-rays as both the priming and the challenge doses. As studies on AR is expected to provide important scientific basis for risk estimates, offer significant insight into the biological defense mechanisms, and lead to possible novel radiotherapy for practical application, a series of work have being done using this AR model in our lab. To date, existence of a mouse strain difference for AR induction was verified and confirmed. Recently, AR induction was found to be dependent on the radiation quality when heavy ion particles were applied to this model. Noticeably, it was shown for the first time that AR induction could relieve the late residual anhematopoiesis and delayed genotoxic effects in vivo. These findings were successively presented at the JRRS annual meetings. In the present report results on the effect of diet intake on AR induction will be addressed. C57BL/6J female mice from SLC Japan and a mouse diet MB-1 from Funabashi Farm were used. The post-weaning mice were either allowed to access freely the diet or given with a reduced amount of diet throughout the study. The priming dose and the challenge dose, both from X-rays, were delivered at a postnatal age of 6 and 8 weeks respectively. Thirty-day survival and residual damage in the hematopoietic system in the surviving animals were studied. Results showed that diet intake could play a pivotal role in the AR induction. The findings indicated that a light diet could further suppress the delayed genotoxic effects in this mouse AR model. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本放射線影響学会第56回大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2013-10-20 | |||||
| 日付タイプ | Issued | |||||
