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Analysis of underlying mechanisms for combination therapy of carbon-ion irradiation and dendritic cell immunotherapy.
https://repo.qst.go.jp/records/71285
https://repo.qst.go.jp/records/71285aaee98d6-52cf-42bf-8ce4-bdb2668c8410
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-10-10 | |||||
| タイトル | ||||||
| タイトル | Analysis of underlying mechanisms for combination therapy of carbon-ion irradiation and dendritic cell immunotherapy. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shimokawa, Takashi
× Shimokawa, Takashi× Fujita, Hidetoshi× Hosoi, Akihiro× Sato, Katsutoshi× Kakimi, Kazuhiro× Imai, Takashi× 下川 卓志× 藤田 英俊× 佐藤 克俊× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Carbon-ion (C-ion) radiotherapy (RT) is an advanced RT effective in tumors that are resistant to conventional RT due to its biological properties and excellent dose distribution. However, metastasis control is an important issue to improve C-ion RT. We previously reported that the combination of C-ion irradiation with dendritic cell (DC) immunotherapy significantly suppressed lung metastases in murine models, such as NRS1 mouse squamous cell carcinoma cell transplanted C3H/He mouse. However, the underlying mechanisms are still not clearly understood. In this study, we aim to clarify the impact of C-ion irradiation on the combination therapy in terms of immature DC (iDC) activation. To investigate the effect of C-ion irradiation on DC immunotherapy, we examined whether irradiated or non-irradiated cancer cells can activate immature DC cells by co-culture. NRS1 cells were irradiated with C-ion, then co-cultured for three days with iDCs, which were isolated from C3H/He mice. Activation of the DC was evaluated by a flow cytometer and real-time qPCR. It clearly showed that iDCs were effectively activated by C-ion irradiated cancer cells, but not by non-irradiated cancer cells. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 72nd Annual Meeting of the Japanese Cancer Association | |||||
| 発表年月日 | ||||||
| 日付 | 2013-10-05 | |||||
| 日付タイプ | Issued | |||||
