WEKO3
アイテム
乳幼児期ptch1ヘテロ欠損マウスに対する低線量率放射線による発がん影響について
https://repo.qst.go.jp/records/71280
https://repo.qst.go.jp/records/7128050eba045-d055-4213-ba22-fe4b39087f95
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-10-07 | |||||
| タイトル | ||||||
| タイトル | 乳幼児期ptch1ヘテロ欠損マウスに対する低線量率放射線による発がん影響について | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
鶴岡, 千鶴
× 鶴岡, 千鶴× 尚, 奕× 森岡, 孝満× 上西, 睦美× 島田, 義也× 柿沼, 志津子× 鶴岡 千鶴× 尚 奕× 森岡 孝満× 上西 睦美× 島田 義也× 柿沼 志津子 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Particularly since the accident at the Fukushima Daiichi Nuclear Power Plant, the issue of long-term exposure of low-dose-rate gamma-rays, especially to children, is of great concern. We examined the effect of low-dose-rate irradiation on infants using Ptch1 heterozygous mice, which are prone to radiogenic medulloblastomas (MBs). Ptch1 heterozygous mice were irradiated on postnatal day 1 (PN1) or day 4 (PN4) at a dose-rate of 500 mGy/min, or during postnatal day 1 to 4 (PN1-4) at a dose-rate of 0.1 mGy/min, to a total dose of 0.5 Gy. The highest incidence of MB was in mice exposed on PN1, with similar rates in the other two groups and non-irradiated, although MB-free survival was not significantly different from non-irradiated mice at this irradiation dose. We previously reported that loss of heterozygosity (LOH) at chromosome 13 including Ptch1 locus in spontaneous MBs arises from mitotic recombination, while those in radiation-induced MBs arose from interstitial deletions. We are analyzing LOH at chromosome 13 to determine the molecular mechanism of LOH in MBs induced by low-dose-rate irradiation. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第72回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2013-10-05 | |||||
| 日付タイプ | Issued | |||||
