@misc{oai:repo.qst.go.jp:00071280,
 author = {鶴岡, 千鶴 and 尚, 奕 and 森岡, 孝満 and 上西, 睦美 and 島田, 義也 and 柿沼, 志津子 and 鶴岡 千鶴 and 尚 奕 and 森岡 孝満 and 上西 睦美 and 島田 義也 and 柿沼 志津子},
 month = {Oct},
 note = {Particularly since the accident at the Fukushima Daiichi Nuclear Power Plant, the issue of long-term exposure of low-dose-rate gamma-rays, especially to children, is of great concern.  We examined the effect of low-dose-rate irradiation on infants using Ptch1 heterozygous mice, which are prone to radiogenic medulloblastomas (MBs). Ptch1 heterozygous mice were irradiated on postnatal day 1 (PN1) or day 4 (PN4) at a dose-rate of 500 mGy/min, or during postnatal day 1 to 4 (PN1-4) at a dose-rate of 0.1 mGy/min, to a total dose of 0.5 Gy. The highest incidence of MB was in mice exposed on PN1, with similar rates in the other two groups and non-irradiated, although MB-free survival was not significantly different from non-irradiated mice at this irradiation dose. We previously reported that loss of heterozygosity (LOH) at chromosome 13 including Ptch1 locus in spontaneous MBs arises from mitotic recombination, while those in radiation-induced MBs arose from interstitial deletions. We are analyzing LOH at chromosome 13 to determine the molecular mechanism of LOH in MBs induced by low-dose-rate irradiation., 第72回日本癌学会学術総会},
 title = {乳幼児期ptch1ヘテロ欠損マウスに対する低線量率放射線による発がん影響について},
 year = {2013}
}