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Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation.
https://repo.qst.go.jp/records/71254
https://repo.qst.go.jp/records/71254073a3bda-2efd-413a-a8cd-20fac004a3a7
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-09-24 | |||||
| タイトル | ||||||
| タイトル | Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hong, Zhang
× Hong, Zhang× Bing, Wang× Tanaka, Kaoru× Ninomiya, Yasuharu× Zhou, Xin× Zhang, Xin× Xie, Yi× Ｈｏｎｇ Ｚｈａｎｇ× 王 冰× 田中 薫× 二宮 康晴× Ｚｈｏｕ Ｘｉｎ× Ｚｈａｎｇ Ｘｉｎ× Ｘｉｅ Ｙｉ |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Our previous works showed that carbon-ion irradiation of MCF-7 cells exhibited elevated radiosensitivity with DNA-PKcs inhibition. Inhibition of DNA-PKcs combined with carbon-ion radiation led to accelerated telomere loss and senescence. However, direct evidences supporting that telomere length was related to radiosensitivity were needed. In this year, MCF-7 cells with shorter telomere length were established by continuous incubation with specific telomerase inhibitor MST-312. MCF-7 cells with shorter telomere were found to be more susceptive to carbon-ion irradiation. Carbon-ion radiation alone induced G2-M cell cycle arrest, while combined with MST-312 incubation, the cell cycle arrest shift to G1-S arrest. Current data supported the telomere length was related to radioresistance in cancer cells. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成24年度HIMAC共同利用研究成果発表会. | |||||
| 発表年月日 | ||||||
| 日付 | 2013-04-23 | |||||
| 日付タイプ | Issued | |||||
