{"created":"2023-05-15T14:52:10.533946+00:00","id":71254,"links":{},"metadata":{"_buckets":{"deposit":"f918b8f6-505a-44d7-8221-da5538c6633e"},"_deposit":{"created_by":1,"id":"71254","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71254"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071254","sets":["10:28"]},"author_link":["700439","700432","700442","700435","700438","700441","700440","700443","700434","700437","700444","700433","700436","700445"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-04-23","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Our previous works showed that carbon-ion irradiation of MCF-7 cells exhibited elevated radiosensitivity with DNA-PKcs inhibition. Inhibition of DNA-PKcs combined with carbon-ion radiation led to accelerated telomere loss and senescence. However, direct evidences supporting that telomere length was related to radiosensitivity were needed. In this year, MCF-7 cells with shorter telomere length were established by continuous incubation with specific telomerase inhibitor MST-312. MCF-7 cells with shorter telomere were found to be more susceptive to carbon-ion irradiation. Carbon-ion radiation alone induced G2-M cell cycle arrest, while combined with MST-312 incubation, the cell cycle arrest shift to G1-S arrest. Current data supported the telomere length was related to radioresistance in cancer cells.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"平成24年度HIMAC共同利用研究成果発表会.","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hong, Zhang"}],"nameIdentifiers":[{"nameIdentifier":"700432","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"700433","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"700434","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ninomiya, Yasuharu"}],"nameIdentifiers":[{"nameIdentifier":"700435","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhou, Xin"}],"nameIdentifiers":[{"nameIdentifier":"700436","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Xin"}],"nameIdentifiers":[{"nameIdentifier":"700437","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Xie, Yi"}],"nameIdentifiers":[{"nameIdentifier":"700438","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｈｏｎｇ Ｚｈａｎｇ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"700439","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"700440","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"700441","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"二宮 康晴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"700442","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｚｈｏｕ Ｘｉｎ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"700443","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｚｈａｎｇ Ｘｉｎ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"700444","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｘｉｅ Ｙｉ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"700445","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation."}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-09-24"},"publish_date":"2013-09-24","publish_status":"0","recid":"71254","relation_version_is_last":true,"title":["Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:53:23.656244+00:00"}