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X-ray irradiation suppresses SLE-like morbidity in NZBWF1 mice.
https://repo.qst.go.jp/records/71253
https://repo.qst.go.jp/records/712536e658cbf-c2d3-44d7-a7e2-1ff4de57e9bb
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-09-24 | |||||
| タイトル | ||||||
| タイトル | X-ray irradiation suppresses SLE-like morbidity in NZBWF1 mice. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujita, Kazuko
× Fujita, Kazuko× Bing, Wang× Kuwabara, Taku× Kamata, Itaru× Tanaka, Kaoru× Akasaka, Yoshikiyo× Ishii, Toshiharu× 藤田 和子× 王 冰× 桑原 卓× 田中 薫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | CD180 molecule is a homologue of TLR-4 and expresses on mature B cells. The molecule shows a protective effect against radiation- or dexamethasone-induced apoptosis in vitro. CD180 is a key regulator of cell proliferation and death. We previously showed CD180-negative spleen B cells exhibited sensitivity for radiation-induced apoptosis compared with CD180-positive cells in vivo. In SLE patients, the number of CD180-negative B cells increased in peripheral blood, and appeared to be associated with the activity of SLE. In addition, such negative cells collected from SLE patients produced autoantibodies in vitro. We previously reported CD180-negative B cells might lead to development of SLE morbidity in SLE-model mouse, NZBWF1. In the present study, we attempted to examine the effects of X-ray irradiation on CD180-negative B cells in NZBWF1 female mice. After irradiation, the mean life span of the irradiated mouse group was significantly extended compared with that of the sham-irradiated one. In addition, the latency to the development of grade three-proteinuria in irradiated mouse is significantly longer than in sham-irradiated one. The amount of complement C3 in peripheral blood of the irradiated mouse was sustained at normal level, while that of sham-irradiated mouse was markedly decreased at 3 weeks after sham-irradiation. These findings suggest that radiation could effectively eliminate CD180-negative B cells, leading to reduction of autoantibody production, and thus relieve SLE symptoms. The findings also suggest a possibility that the radiotherapy into autoimmune diseases associated with the expression of CD180-negative cells might be a novel practical application. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 15th International Congress of Immunology (第15回国際免疫学会議). | |||||
| 発表年月日 | ||||||
| 日付 | 2013-08-27 | |||||
| 日付タイプ | Issued | |||||
