@misc{oai:repo.qst.go.jp:00071253,
 author = {Fujita, Kazuko and Bing, Wang and Kuwabara, Taku and Kamata, Itaru and Tanaka, Kaoru and Akasaka, Yoshikiyo and Ishii, Toshiharu and 藤田 和子 and 王 冰 and 桑原 卓 and 田中 薫},
 month = {Aug},
 note = {CD180 molecule is a homologue of TLR-4 and expresses on mature B cells. The molecule shows a protective effect against radiation- or dexamethasone-induced apoptosis in vitro. CD180 is a key regulator of cell proliferation and death. We previously showed CD180-negative spleen B cells exhibited sensitivity for radiation-induced apoptosis compared with CD180-positive cells in vivo. In SLE patients, the number of CD180-negative B cells increased in peripheral blood, and appeared to be associated with the activity of SLE. In addition, such negative cells collected from SLE patients produced autoantibodies in vitro. We previously reported CD180-negative B cells might lead to development of SLE morbidity in SLE-model mouse, NZBWF1. In the present study, we attempted to examine the effects of X-ray irradiation on CD180-negative B cells in NZBWF1 female mice. After irradiation, the mean life span of the irradiated mouse group was significantly extended compared with that of the sham-irradiated one. In addition, the latency to the development of grade three-proteinuria in irradiated mouse is significantly longer than in sham-irradiated one. The amount of complement C3 in peripheral blood of the irradiated mouse was sustained at normal level, while that of sham-irradiated mouse was markedly decreased at 3 weeks after sham-irradiation. These findings suggest that radiation could effectively eliminate CD180-negative B cells, leading to reduction of autoantibody production, and thus relieve SLE symptoms. The findings also suggest a possibility that the radiotherapy into autoimmune diseases associated with the expression of CD180-negative cells might be a novel practical application., 15th International Congress of Immunology (第15回国際免疫学会議).},
 title = {X-ray irradiation suppresses SLE-like morbidity in NZBWF1 mice.},
 year = {2013}
}