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Clinical effects of hyperglycemia on FDG uptake of tumor and brain in patients with suspected cancer.
https://repo.qst.go.jp/records/71230
https://repo.qst.go.jp/records/71230b8df2616-40eb-448c-8933-8d25f4a47121
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-09-03 | |||||
| タイトル | ||||||
| タイトル | Clinical effects of hyperglycemia on FDG uptake of tumor and brain in patients with suspected cancer. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hara, Tadashi
× Hara, Tadashi× Higashi, Tatsuya× Ishizu, Koichi× Suga, Tsuyoshi× Nakamoto, Yuji× Saga, Tsuneo× Togashi, Kaori× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: The purpose of this study was to evaluate the effects of hyperglycemia on FDG uptake of the brain, liver, muscle and tumor in clinical situation. Methods: Fifty-seven patients (mean age: 64.8+-8.9, range: 42-79, male : female=40 : 17) who showed blood glucose level more than 200 mg/dl at the time of examination (mean glucose level: 255.5+-69.3, range: 201-666) were included in this retrospective study. All patients received FDG-PET scan for suspected cancer in Kyoto University Hospital from January 2001 to December 2005 and fasted at least 4 hours before PET study. Reasons of hyperglycemia were follows; untreated diabetes: n=5, uncontrolled diabetes: n=32, unknown: n=20. FDG accumulation of the tumor was visually analyzed. SUV of the brain, liver, muscle and tumor were also analyzed. Results: Presence or absence of malignant lesion was confirmed by other modality such as CT, surgery, and clinical follow-up at least 6 month in 49 patients and malignant lesion(s) were finally diagnosed in 35 patients. Twenty eight of 35 patients had positive results by visual analysis (lung cancer: 7, pancreas cancer: 7, liver metastases: 3, lung metastases: 3, hepatocellular carcinoma: 2, bone metastases: 2, etc.) and the average of tumor SUV was 5.7+-2.5. False negative results were observed in 7 cases which consisted of so-called low-FDG-avid tumors (hepatocellular carcinoma: 3, pancreas cancer: 3, small lung metastasis from pancreas cancer: 1) and the average of tumor SUV was 2.7+-0.8. In contrast to relatively stable tumor FDG uptake, brain FDG uptake tended to be lower in this high glucose level (SUV=4.4+-1.1), as compared to that in normoglycemia (SUV=11.8+-2.6). Liver, muscle and tumor FDG uptake didnt show clear correlation with blood glucose level. Specificity, sensitivity and PPV of FDG-PET scan were 67%, 97% and 80% respectively. Conclusions: In spite of high blood glucose level (more than 200 mg/dl), FDG uptake of the tumor maintained enough high level for visual diagnosis in majority of cases, except for the cases of low-FDG-avid tumors, such as hepatocellular carcinoma and pancreas cancer. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Society of nuclear medicine 54rd Annual Meetng | |||||
| 発表年月日 | ||||||
| 日付 | 2007-06-06 | |||||
| 日付タイプ | Issued | |||||
