WEKO3
-
RootNode
アイテム
Splenic lymphomas of Mlh1-deficient mice induced by in utero irradiation are derived from invariant natural killer T cell.
https://repo.qst.go.jp/records/71165
https://repo.qst.go.jp/records/71165d7a9d0cc-b11e-45a2-8b0a-63293b02aec6
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-06-20 | |||||
| タイトル | ||||||
| タイトル | Splenic lymphomas of Mlh1-deficient mice induced by in utero irradiation are derived from invariant natural killer T cell. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kakinuma, Shizuko
× Kakinuma, Shizuko× Hirano, Shinobu× Fujimoto, Shinji× Takimoto, Misaki× Amasaki, Yoshiko× Nishimura, Mayumi× Shimada, Yoshiya× 柿沼 志津子× 坂入 しのぶ× 滝本 美咲× 甘崎 佳子× 西村 まゆみ× 島田 義也 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Deficiencies in DNA mismatch repair (MMR) result in replication errors that cause frameshift mutations and/or point mutations within key tumor suppressor genes or oncogenes. Homozygous germline mutations of MMR genes, such as MLH1, MSH2 and PMS2, are manifested by early onset childhood T- or B-cell leukemia. Mlh1-/- mice develop aggressive thymic lymphomas. We previously showed that spontaneously developed Mlh1-/- thymic lymphomas harbored frequent frameshift mutations in Ikaros, a master transcription factor of lymphoid lineage commitment and differentiation. In this study, we examined the effect of fetal radiation exposure on lymphomgenesis in Mlh1-/- mice. Exposure to radiation after birth increased the incidence of thymic lymphomas and shortened their latency. Point mutations and frameshift mutation in Ikaros were generated in radiation-induced lymphomas. In utero radiation exposure, unexpectedly, resulted in no effect on thymic lymphomagenesis, but accelerated splenic lymphomagenesis. Analysis of TCRa and b rearrangement revealed that a half of splenic lymphomas and all lymphomas expressing TCR expressed the Va14−Ja18 rearrangement paired with either Vb-8, -7 or -2, which is specific for invariant natural killer T cell. Mechanisms of lymphomagenesis of iNKT cells are remained to be studied. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 6th International Workshop of Kyoto T Cell Conference (KTCC2013) | |||||
| 発表年月日 | ||||||
| 日付 | 2013-06-07 | |||||
| 日付タイプ | Issued | |||||
Share
Cite as
Kakinuma, Shizuko, Hirano, Shinobu, Fujimoto, Shinji, Takimoto, Misaki, Amasaki, Yoshiko, Nishimura, Mayumi, Shimada, Yoshiya, 柿沼 志津子, 坂入 しのぶ, 滝本 美咲, 甘崎 佳子, 西村 まゆみ, 島田 義也, 2013, Splenic lymphomas of Mlh1-deficient mice induced by in utero irradiation are derived from invariant natural killer T cell.
