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Splenic lymphomas of Mlh1-deficient mice induced by in utero irradiation are derived from invariant natural killer T cell.
https://repo.qst.go.jp/records/71165
https://repo.qst.go.jp/records/71165d7a9d0cc-b11e-45a2-8b0a-63293b02aec6
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-06-20 | |||||
| タイトル | ||||||
| タイトル | Splenic lymphomas of Mlh1-deficient mice induced by in utero irradiation are derived from invariant natural killer T cell. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kakinuma, Shizuko
× Kakinuma, Shizuko× Hirano, Shinobu× Fujimoto, Shinji× Takimoto, Misaki× Amasaki, Yoshiko× Nishimura, Mayumi× Shimada, Yoshiya× 柿沼 志津子× 坂入 しのぶ× 滝本 美咲× 甘崎 佳子× 西村 まゆみ× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Deficiencies in DNA mismatch repair (MMR) result in replication errors that cause frameshift mutations and/or point mutations within key tumor suppressor genes or oncogenes. Homozygous germline mutations of MMR genes, such as MLH1, MSH2 and PMS2, are manifested by early onset childhood T- or B-cell leukemia. Mlh1-/- mice develop aggressive thymic lymphomas. We previously showed that spontaneously developed Mlh1-/- thymic lymphomas harbored frequent frameshift mutations in Ikaros, a master transcription factor of lymphoid lineage commitment and differentiation. In this study, we examined the effect of fetal radiation exposure on lymphomgenesis in Mlh1-/- mice. Exposure to radiation after birth increased the incidence of thymic lymphomas and shortened their latency. Point mutations and frameshift mutation in Ikaros were generated in radiation-induced lymphomas. In utero radiation exposure, unexpectedly, resulted in no effect on thymic lymphomagenesis, but accelerated splenic lymphomagenesis. Analysis of TCRa and b rearrangement revealed that a half of splenic lymphomas and all lymphomas expressing TCR expressed the Va14−Ja18 rearrangement paired with either Vb-8, -7 or -2, which is specific for invariant natural killer T cell. Mechanisms of lymphomagenesis of iNKT cells are remained to be studied. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 6th International Workshop of Kyoto T Cell Conference (KTCC2013) | |||||
| 発表年月日 | ||||||
| 日付 | 2013-06-07 | |||||
| 日付タイプ | Issued | |||||
