{"created":"2023-05-15T14:52:04.707672+00:00","id":71165,"links":{},"metadata":{"_buckets":{"deposit":"115d8ae7-bffc-42c6-bd87-95059cb3e7e0"},"_deposit":{"created_by":1,"id":"71165","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71165"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071165","sets":["10:28"]},"author_link":["699626","699624","699625","699618","699617","699616","699620","699619","699614","699615","699621","699623","699622"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-06-07","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Deficiencies in DNA mismatch repair (MMR) result in replication errors that cause frameshift mutations and/or point mutations within key tumor suppressor genes or oncogenes. Homozygous germline mutations of MMR genes, such as MLH1, MSH2 and PMS2, are manifested by early onset childhood T- or B-cell leukemia. Mlh1-/- mice develop aggressive thymic lymphomas. We previously showed that spontaneously developed Mlh1-/- thymic lymphomas harbored frequent frameshift mutations in Ikaros, a master transcription factor of lymphoid lineage commitment and differentiation. In this study, we examined the effect of fetal radiation exposure on lymphomgenesis in Mlh1-/- mice. Exposure to radiation after birth increased the incidence of thymic lymphomas and shortened their latency. Point mutations and frameshift mutation in Ikaros were generated in radiation-induced lymphomas. In utero radiation exposure, unexpectedly, resulted in no effect on thymic lymphomagenesis, but accelerated splenic lymphomagenesis. Analysis of TCRa and b rearrangement revealed that a half of splenic lymphomas and all lymphomas expressing TCR expressed the Va14−Ja18 rearrangement paired with either Vb-8, -7 or -2, which is specific for invariant natural killer T cell. Mechanisms of lymphomagenesis of iNKT cells are remained to be studied.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"6th International Workshop of Kyoto T Cell Conference (KTCC2013)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"699614","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirano, Shinobu"}],"nameIdentifiers":[{"nameIdentifier":"699615","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujimoto, Shinji"}],"nameIdentifiers":[{"nameIdentifier":"699616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takimoto, Misaki"}],"nameIdentifiers":[{"nameIdentifier":"699617","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Amasaki, Yoshiko"}],"nameIdentifiers":[{"nameIdentifier":"699618","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"699619","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"699620","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699621","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂入 しのぶ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699622","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"滝本 美咲","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699623","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"甘崎 佳子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699624","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699625","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"699626","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Splenic lymphomas of Mlh1-deficient mice induced by in utero irradiation are derived from invariant natural killer T cell.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Splenic lymphomas of Mlh1-deficient mice induced by in utero irradiation are derived from invariant natural killer T cell."}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-06-20"},"publish_date":"2013-06-20","publish_status":"0","recid":"71165","relation_version_is_last":true,"title":["Splenic lymphomas of Mlh1-deficient mice induced by in utero irradiation are derived from invariant natural killer T cell."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:54:26.816756+00:00"}