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PET imaging and quantification of the effects of succinylated gelatin and/or L-lysine on renal uptake and retention of the novel radiopharmaceutical 64Cu-cyclam-RAFT-c(-RGDfK-)4
https://repo.qst.go.jp/records/71164
https://repo.qst.go.jp/records/7116450c9dddc-5038-46a6-af5b-ed637db4e882
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-06-20 | |||||
| タイトル | ||||||
| タイトル | PET imaging and quantification of the effects of succinylated gelatin and/or L-lysine on renal uptake and retention of the novel radiopharmaceutical 64Cu-cyclam-RAFT-c(-RGDfK-)4 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Jin, Zhao-Hui
× Jin, Zhao-Hui× Furukawa, Takako× Sogawa, Chizuru× Tsuji, Atsushi× U, Winn Aung× Coll, Jean-Luc× Saga, Tsuneo× et.al× 金 朝暉× 古川 高子× 曽川 千鶴× 辻 厚至× Ｕ Ｗｉｎｎ Ａｕｎｇ× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: 64Cu-cyclam-RAFT-c(-RGDfK-)4 (64Cu-RAFTRGD) is a novel tetrameric cyclic RGD peptide probe for PET imaging of tumor angiogenesis via targeting the V3 integrin. Because 64Cu also emits -, it can be used for internal radiotherapy. We studied the effects of a succinylated gelatin-containing plasma expander Gelofusine and L-lysine on the renal uptake and retention of 64Cu-RAFTRGD in tumor-bearing mice, aiming to find measures to lower the risk of nephrotoxicity in internal radiotherapy using 64Cu-RAFTRGD. Methods: Normal or tumor-bearing mice received injection of 64Cu-RAFTRGD with or without co-injection of Gelofusine, L-lysine, or the both. Biodistribution studies were performed at 3 and 24 h post-injection (p.i.). Dynamic PET scans (5 min/frame) were performed at 0-60 min p.i., followed by static PET scans at 3.5 and 24 h p.i. Radio-TLC was done to analyze the radioactive metabolites in blood, urine, liver, and kidney samples at 1 and 24 h p.i. Results: Co-injection of Gelofusine significantly reduced the renal uptake and retention of 64Cu-RAFTRGD. Although L-lysine alone had no influence on the renal radioactivity accumulation, it showed the tendency to enhance the inhibitory effect of Gelofusine. The uptake of 64Cu-RAFTRGD in the tumors was not influenced by co-injection of Gelofusine or together with L-lysine. Dynamic PET imaging of mice and metabolic analysis of tissue samples clearly showed that Gelofusine did block the renal reabsorption of 64Cu-RAFTRGD, and did not interfere with the metabolism and excretion pathway of the probe. Conclusion: Administration of Gelofusine or together with L-lysine is a promising measure for kidney protection in internal radiotherapy using 64Cu-RAFTRGD. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | SNMMI 2013 Annual Meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2013-06-12 | |||||
| 日付タイプ | Issued | |||||
