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Recent outcome on age and tissue dependence of radiation carcinogenesis in mice and rats
https://repo.qst.go.jp/records/71147
https://repo.qst.go.jp/records/711472f22c878-e950-4207-9503-38fa905d646c
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-06-13 | |||||
| タイトル | ||||||
| タイトル | Recent outcome on age and tissue dependence of radiation carcinogenesis in mice and rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shimada, Yoshiya
× Shimada, Yoshiya× Nishimura, Mayumi× Imaoka, Tatsuhiko× Daino, Kazuhiro× Yamada, Yutaka× Homma-Takeda, Shino× Amasaki, Yoshiko× Shang, Yi× Sawai, Tomoko× Hirano, Shinobu× Iwata, Ken-ichi× Morioka, Takamitsu× Tsuruoka, Chizuru× Blyth, Benjamin× Tani, Shusuke× Hosoki, Ayaka× Ariyoshi, Kentaro× Kokubo, Toshiaki× Ishida, Yuka× Kakinuma, Shizuko× 島田 義也× 西村 まゆみ× 今岡 達彦× 臺野 和広× 山田 裕× 武田 志乃× 甘崎 佳子× 尚 奕× 澤井 知子× 坂入 しのぶ× 岩田 健一× 森岡 孝満× 鶴岡 千鶴× Ｂｌｙｔｈ Ｂｅｎｊａｍｉｎ× 谷 修祐× 細木 彩夏× 有吉 健太郎× 小久保 年章× 石田 有香× 柿沼 志津子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation is a useful tool for disease diagnosis and therapy. On the other hand, a risk of subsequent malignant neoplasms several decades after receiving radiation is a serious public concern. In this study, we introduce our current program on the carcinogenic effect of early-life exposure to radiation using mouse and rat models. We here show that there exist susceptible age windows for radiation carcinogenesis in a tissue dependent manner. Perinatal period is the most susceptible for radiation-induction of both medulloblastomas and renal cell carcinomas. Irradiation at neonatal and infant age efficiently induces intestinal and liver tumors. Mammary cancers develop frequently at around pubertal exposure. Conversely, the incidence of lung cancers rather increases as a function of age-at-exposure. Underlying mechanisms include age dependent changes in the rate of clonal expansion and susceptibility to radiation-induced cell killing of the progenitor cells. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 3rd Asian Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2013-05-15 | |||||
| 日付タイプ | Issued | |||||
