@misc{oai:repo.qst.go.jp:00071147, author = {Shimada, Yoshiya and Nishimura, Mayumi and Imaoka, Tatsuhiko and Daino, Kazuhiro and Yamada, Yutaka and Homma-Takeda, Shino and Amasaki, Yoshiko and Shang, Yi and Sawai, Tomoko and Hirano, Shinobu and Iwata, Ken-ichi and Morioka, Takamitsu and Tsuruoka, Chizuru and Blyth, Benjamin and Tani, Shusuke and Hosoki, Ayaka and Ariyoshi, Kentaro and Kokubo, Toshiaki and Ishida, Yuka and Kakinuma, Shizuko and 島田 義也 and 西村 まゆみ and 今岡 達彦 and 臺野 和広 and 山田 裕 and 武田 志乃 and 甘崎 佳子 and 尚 奕 and 澤井 知子 and 坂入 しのぶ and 岩田 健一 and 森岡 孝満 and 鶴岡 千鶴 and Blyth Benjamin and 谷 修祐 and 細木 彩夏 and 有吉 健太郎 and 小久保 年章 and 石田 有香 and 柿沼 志津子}, month = {May}, note = {Radiation is a useful tool for disease diagnosis and therapy. On the other hand, a risk of subsequent malignant neoplasms several decades after receiving radiation is a serious public concern. In this study, we introduce our current program on the carcinogenic effect of early-life exposure to radiation using mouse and rat models. We here show that there exist susceptible age windows for radiation carcinogenesis in a tissue dependent manner. Perinatal period is the most susceptible for radiation-induction of both medulloblastomas and renal cell carcinomas. Irradiation at neonatal and infant age efficiently induces intestinal and liver tumors. Mammary cancers develop frequently at around pubertal exposure. Conversely, the incidence of lung cancers rather increases as a function of age-at-exposure. Underlying mechanisms include age dependent changes in the rate of clonal expansion and susceptibility to radiation-induced cell killing of the progenitor cells., The 3rd Asian Congress of Radiation Research}, title = {Recent outcome on age and tissue dependence of radiation carcinogenesis in mice and rats}, year = {2013} }