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Aggregation of 53BP1 and XRCC1 in Cancer Stem Cells and Non-stem Cancer Cells post Targeted proton irradiation
https://repo.qst.go.jp/records/71122
https://repo.qst.go.jp/records/7112277fdaeb5-250d-4f5e-92d0-25562b25b65f
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-05-31 | |||||
| タイトル | ||||||
| タイトル | Aggregation of 53BP1 and XRCC1 in Cancer Stem Cells and Non-stem Cancer Cells post Targeted proton irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yang, Gen
× Yang, Gen× Konishi, Teruaki× Kobayashi, Alisa× Maeda, Takeshi× Uchihori, Yukio× K, Hei Tom× Wang, Yugang× 小西 輝昭× 小林 亜利紗× 前田 武× 内堀 幸夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Tumor cells often exist in different phenotypes with distinct properties. Ever increasing evidence strongly surpported the existence of the cancer stem cells (CSCs) and non-stem cancer cells (NSCCs) in various tumors. It is of fundamental importance to understand the properties of the phenotypes under radiation and chemical treatments, for CSCs are regarded as the source of tumor dormancy as well as recurrence after apparently successful debulking of human solid tumors by various forms of therapy. To understand the DNA damages and repairs in CSCs/NSCCs post radiation, presently sorted CSCs/NSCCs were irradiated with SPICE microbeam facility. The results showed that the aggregation of 53BP1 and XRCC1 are in a dose-dependent manner from 20 protons to 200 protons per nucleus. In addition, compared with NSCCs, there is lower average related fluorescence unit in 53BP1 foci induced by proton radiation, indicating CSCs might be more radioresistant than that of NSCCs. Importantly, significant higher disappearation rate of the fluorescence also observed in CSCs than that of NSCCs, indicating CSCs may have higher rapair efficiency than that of NSCCs post proton irradiation. In addition, the radiation induced bystander effects in CSCs and NSCCs were also studied via the aggregation of 53BP1. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Heavy Ion in Therapy and Space Radiation Spymposium 2013 | |||||
| 発表年月日 | ||||||
| 日付 | 2013-05-18 | |||||
| 日付タイプ | Issued | |||||
