@misc{oai:repo.qst.go.jp:00071122,
 author = {Yang, Gen and Konishi, Teruaki and Kobayashi, Alisa and Maeda, Takeshi and Uchihori, Yukio and K, Hei Tom and Wang, Yugang and 小西 輝昭 and 小林 亜利紗 and 前田 武 and 内堀 幸夫},
 month = {May},
 note = {Tumor cells often exist in different phenotypes with distinct properties. Ever increasing evidence strongly surpported the existence of the cancer stem cells (CSCs) and non-stem cancer cells (NSCCs) in various tumors. It is of fundamental importance to understand the properties of the phenotypes under radiation and chemical treatments, for CSCs are regarded as the source of tumor dormancy as well as recurrence after apparently successful debulking of human solid tumors by various forms of therapy. To understand the DNA damages and repairs in CSCs/NSCCs post radiation, presently sorted CSCs/NSCCs were irradiated with SPICE microbeam facility. The results showed that the aggregation of 53BP1 and XRCC1 are in a dose-dependent manner from 20 protons to 200 protons per nucleus. In addition, compared with NSCCs, there is lower average related fluorescence unit in 53BP1 foci induced by proton radiation, indicating CSCs might be more radioresistant than that of NSCCs. Importantly, significant higher disappearation rate of the fluorescence also observed in CSCs than that of NSCCs, indicating CSCs may have higher rapair efficiency than that of NSCCs post proton irradiation. In addition, the radiation induced bystander effects in CSCs and NSCCs were also studied via the aggregation of 53BP1., Heavy Ion in Therapy and Space Radiation Spymposium 2013},
 title = {Aggregation of 53BP1 and XRCC1 in Cancer Stem Cells and Non-stem Cancer Cells post Targeted proton irradiation},
 year = {2013}
}