WEKO3
アイテム
Tissue redox activity as a sensing platform for magnetic resonance imaging of cancer based on nitroxide redox cycle
https://repo.qst.go.jp/records/71090
https://repo.qst.go.jp/records/7109065da750d-38a4-427c-b1b1-1e5660ebd7ff
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-05-07 | |||||
| タイトル | ||||||
| タイトル | Tissue redox activity as a sensing platform for magnetic resonance imaging of cancer based on nitroxide redox cycle | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Bakalova-Zheleva, Rumiana
× Bakalova-Zheleva, Rumiana× Zhelev, Zhivko× Aoki, Ichio× Kokuryo, Daisuke× Saga, Tsuneo× et.al× バカロバ ルミアナ× Ｚｈｅｌｅｖ Ｚｈｉｖｋｏ× 青木 伊知男× 國領 大介× 佐賀 恒夫 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The experience in free radical biology and medicine shows the crucial role of redox signalling in carcinogenesis. The cells and tissues of healthy mammals are characterized by a low level of reactive oxygen species (ROS) and some constant (reference) level of reducing equivalents. Increasing of ROS above the critical level provokes genomic instability. The present study describes universal methodology for direct imaging of tissue redox activity in carcinogenesis, which allows a differentiation of cancer development from normal condition. The experiments were conducted on neuroblastoma-, glioma-, and colon cancer-bearing mice, as well as on healthy mice. The tissue redox activity was visualized in vivo by nitroxide-enhanced MRI on anesthetized animals. The method is based on nitroxide redox cycle, coupled with appearance/disappearance of MRI signal. The duration and half-life (1/2) of nitroxide-enhanced MRI signal in the respective tissue was used as a diagnostic marker. The study provides direct evidence that healthy and cancer-bearing mammalian tissues are characterized by different redox activity – a basis for cancer diagnostic. The tissues (cancer and “normal”) of cancer-bearing mammals were characterized by a long-lived MRI signal (1/2 > 14 min), indicating a high oxidative activity (Figure). The tissues of healthy organism were characterized by a short-lived MRI signal (1/2 = 1 - 3 min), indicating a high reducing activity. The study shows that tissue redox activity is a sensing platform for imaging of cancer using nitroxide-enhanced MRI. It also suggests that “normal” tissues of cancer-bearing organism are susceptible to oxidative damage. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ISMRM 21th Annual Meeting and Exhibition | |||||
| 発表年月日 | ||||||
| 日付 | 2013-04-26 | |||||
| 日付タイプ | Issued | |||||
