@misc{oai:repo.qst.go.jp:00071090,
 author = {Bakalova-Zheleva, Rumiana and Zhelev, Zhivko and Aoki, Ichio and Kokuryo, Daisuke and Saga, Tsuneo and et.al and バカロバ ルミアナ and Ｚｈｅｌｅｖ Ｚｈｉｖｋｏ and 青木 伊知男 and 國領 大介 and 佐賀 恒夫},
 month = {Apr},
 note = {The experience in free radical biology and medicine shows the crucial role of redox signalling in carcinogenesis. The cells and tissues of healthy mammals are characterized by a low level of reactive oxygen species (ROS) and some constant (reference) level of reducing equivalents. Increasing of ROS above the critical level provokes genomic instability. The present study describes universal methodology for direct imaging of tissue redox activity in carcinogenesis, which allows a differentiation of cancer development from normal condition. The experiments were conducted on neuroblastoma-, glioma-, and colon cancer-bearing mice, as well as on healthy mice. The tissue redox activity was visualized in vivo by nitroxide-enhanced MRI on anesthetized animals. The method is based on nitroxide redox cycle, coupled with appearance/disappearance of MRI signal. The duration and half-life (1/2) of nitroxide-enhanced MRI signal in the respective tissue was used as a diagnostic marker. The study provides direct evidence that healthy and cancer-bearing mammalian tissues are characterized by different redox activity – a basis for cancer diagnostic. The tissues (cancer and “normal”) of cancer-bearing mammals were characterized by a long-lived MRI signal (1/2 > 14 min), indicating a high oxidative activity (Figure). The tissues of healthy organism were characterized by a short-lived MRI signal (1/2 = 1 - 3 min), indicating a high reducing activity. The study shows that tissue redox activity is a sensing platform for imaging of cancer using nitroxide-enhanced MRI. It also suggests that “normal” tissues of cancer-bearing organism are susceptible to oxidative damage., ISMRM 21th Annual Meeting and Exhibition},
 title = {Tissue redox activity as a sensing platform for magnetic resonance imaging of cancer based on nitroxide redox cycle},
 year = {2013}
}