WEKO3
アイテム
Comparison of SUVmax and SUVpeak measuring FDG uptake for robust predictions of patient prognosis of pancreas cancer treated by carbon ion radiotherapy
https://repo.qst.go.jp/records/70976
https://repo.qst.go.jp/records/709764bdbece8-5faa-44ca-a277-ccb2cc8f7e54
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-11-12 | |||||
| タイトル | ||||||
| タイトル | Comparison of SUVmax and SUVpeak measuring FDG uptake for robust predictions of patient prognosis of pancreas cancer treated by carbon ion radiotherapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yoshikawa, Kyosan
× Yoshikawa, Kyosan× Ohashi, Seiya× Toubaru, Sachiko× Hasebe, Mitsuhiko× Tamura, Katsumi× Shiraishi, Takahiro× Tanimoto, Katsuyuki× Yamada, Shigeru× Kandatsu, Susumu× Fukumura, Toshimitsu× Saga, Tsuneo× Kamada, Tadashi× 吉川 京燦× 大橋 靖也× 桃原 幸子× 長谷部 充彦× 田村 克巳× 白石 貴博× 谷本 克之× 山田 滋× 神立 進× 福村 利光× 佐賀 恒夫× 鎌田 正 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Various parameters are used for measuring tumor glucose metabolic activity with 18F-FDG PET including measuring the single maximum pixel value within the slice with highest radioactivity concentration (SUVmax) or placing a fixed ROI in the area of the tumor with the highest level of 18F-FDG uptake (SUVpeak), which it defines as the largest possible mean value of a 1 cm3 spherical VOI positioned within a tumor. SUVmax is avoided inter-observer variation, but a major drawback of this approach is its susceptibility to noise in the data. SUVpeak is also removed inter-observer variation, and the averaging of multiple voxels reduces the susceptibility to noise. In this study we determined which parameter of glucose metabolic activity provided the most robust predictions of patient prognosis of pancreas cancer treated by carbon ion radiotherapy. Materials and Methods: A total of 41 patients (28 males, 13 females; mean age, 65 + 8+- y) with pancreas cancer underwent 18F-FDG PET/CT scan before carbon ion radiotherapy. The following parameters on the pretreatment scans were measured: maximum standardized uptake value (SUVmax), two types of peak SUV (small: SUVpeak5, large: SUVpeak10), and average SUV (SUVave). SUVpeak5 and SUVpeak10 are measured using spherical VOI with radius 5 mm and 10 mm, respectively. SUVave is an average pixel value of the circular ROI with radius 5 mm within the slice with the highest radioactivity concentration. Correlation coefficients were calculated for these parameters, and receiver operating characteristic (ROC) analysis was performed to compare the prediction performance of each parameter for pancreas patients. Results: Pretreatment SUVmax, SUVpeak5, SUVpeak10, and SUVave averaged 6.6, 6.1, 5.1, and 6.0, respectively. Correlation coefficients between all four parameters, SUVmax and SUVpeak5, SUVmax and SUVpeak10, SUVmax and SUVave, SUVpeak5 and SUVpeak10, SUVpeak5 and SUVave, SUVpeak10 and SUVave, were 0.995, 0.964, 0.994, 0.973, 0.995, and 0.969, respectively. The areas under the ROC curve of SUVmax, SUVpeak5, SUVpeak10, and SUVave were 0.69, 0.69, 0.92, and 0.70, respectively. ROC curves of SUVmax, SUVpeak5 and SUVave were closely approximated to each other, but the ROC curve of SUVpeak10 was different from others and much better than others. Conclusions: Four FDG-PET uptake parameters were correlated closely. ROC analysis showed that SUVpeak10 was much better than others for prediction of pancreas patient prognosis. It seemed that relatively large sphere for calculating SUVpeak is better than small sphere if the tumor is large enough for setting the sphere within it. |
|||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Annual Congress of the European Association of Nuclear Medicine | |||||
| 発表年月日 | ||||||
| 日付 | 2012-10-31 | |||||
| 日付タイプ | Issued | |||||
