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Expression of adhesion molecules in cancer cells after low- and high-LET radiation
https://repo.qst.go.jp/records/70967
https://repo.qst.go.jp/records/7096732dbd596-fe50-457f-9ee5-9550aba14db8
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-11-07 | |||||
| タイトル | ||||||
| タイトル | Expression of adhesion molecules in cancer cells after low- and high-LET radiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tinganelli, Walter
× Tinganelli, Walter× Durante, Marco× Hirayama, Ryoichi× Furusawa, Yoshiya× et.al× ティンガネリ ワルター× 平山 亮一× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ionizing radiation affects the mobility and the metastatic potential of tumors. These endpoints are regulated by specific adhesion molecules, such as the E-cadherins and lysyl oxidase (LOX). These molecules are downregulated E-cadherins) and upregulated (LOX) in hypoxia. To study the adhesion molecules and to understand the underlying mechanisms that give to the cells the invasive phenotype, measurements of e-cadherin and LOX protein and gene expression have been performed in irradiated prostate cancer cells. X-rays induced a slight increase of E-cadherin after chronic hypoxic treatment (72 hours 0.5% O2) compared to normoxic cells. A low dose of carbon ion irradiation resulted in an overexpression of E-cadherin, while the opposite was found for X-rays. Implications of these results in radiotherapy will be discussed. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 10th International Symposium on Chromosomal Aberrations | |||||
| 発表年月日 | ||||||
| 日付 | 2012-10-21 | |||||
| 日付タイプ | Issued | |||||
