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カロリー制限による放射線誘発マウス肝がんにおける遺伝子発現の違い
https://repo.qst.go.jp/records/70914
https://repo.qst.go.jp/records/70914389258a7-6289-49e2-83db-3bbec27f2058
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-09-26 | |||||
| タイトル | ||||||
| タイトル | カロリー制限による放射線誘発マウス肝がんにおける遺伝子発現の違い | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
尚, 奕
× 尚, 奕× 柿沼, 志津子× 森岡, 孝満× 小久保, 年章× 島田, 義也× 尚 奕× 柿沼 志津子× 森岡 孝満× 小久保 年章× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The most concern of radiation effect is cancer induction, which tightly links to the increase in mortality and the shortening of life expectancy. Calorie restriction (CR) has emerged as the most potent acting dietary intervention for suppressing cancer risk. Indeed, liver cancer risk is associated with obesity. Earlier we reported the cancer prevention effect of CR on radiation-induced HCC in B6C3F1 mice. In this study, we investigated the characteristic of genomic copy number changes and different gene expression profiles by aCGH and gene expression microarray analyses, respectively, between CR and AL (adlibitum) groups of HCC. We found that aneuploidy rather than short loss or gain was well observed in both CR and AL groups. Results of gene expression microarray analysis showed altered expression level of several genes, which were associated with fatty acid intake or elongation, between AL and CR groups. Our results indicated that altered diet condition might related to different fat metabolism in HCC cells, further correlated with the HCC prevention effect of CR. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第71回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2012-09-21 | |||||
| 日付タイプ | Issued | |||||
