@misc{oai:repo.qst.go.jp:00070914,
 author = {尚, 奕 and 柿沼, 志津子 and 森岡, 孝満 and 小久保, 年章 and 島田, 義也 and 尚 奕 and 柿沼 志津子 and 森岡 孝満 and 小久保 年章 and 島田 義也},
 month = {Sep},
 note = {The most concern of radiation effect is cancer induction, which tightly links to the increase in mortality and the shortening of life expectancy. Calorie restriction (CR) has emerged as the most potent acting dietary intervention for suppressing cancer risk. Indeed, liver cancer risk is associated with obesity. Earlier we reported the cancer prevention effect of CR on radiation-induced HCC in B6C3F1 mice. In this study, we investigated the characteristic of genomic copy number changes and different gene expression profiles by aCGH and gene expression microarray analyses, respectively, between CR and AL (adlibitum) groups of HCC. We found that aneuploidy rather than short loss or gain was well observed in both CR and AL groups. Results of gene expression microarray analysis showed altered expression level of several genes, which were associated with fatty acid intake or elongation, between AL and CR groups. Our results indicated that altered diet condition might related to different fat metabolism in HCC cells, further correlated with the HCC prevention effect of CR., 第71回日本癌学会学術総会},
 title = {カロリー制限による放射線誘発マウス肝がんにおける遺伝子発現の違い},
 year = {2012}
}