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Ｘ線照射後の放射線抵抗性がん細胞株に対する炭素イオン線照射の効果
https://repo.qst.go.jp/records/70913
https://repo.qst.go.jp/records/70913990652b9-45a6-42f5-8211-331745858d80
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-09-26 | |||||
| タイトル | ||||||
| タイトル | Ｘ線照射後の放射線抵抗性がん細胞株に対する炭素イオン線照射の効果 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
佐藤, 克俊
× 佐藤, 克俊× 藤田, 英俊× 今井, 高志× 下川, 卓志× 佐藤 克俊× 藤田 英俊× 今井 高志× 下川 卓志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cancer cells that survive repetitive X-ray irradiation tend to acquire radioresistance, but the mechanisms of the acquired radioresistace are unclear. The aim of this study is to investigate the underlying mechanisms of radioresistance and the effectiveness of carbon ion (C-ion) irradiation on the radioresistant cancer cells. To establish radioresistant cancer cell lines, we repeatedly irradiated a mouse squamous cell carcinoma cell line, NRS1, with X-ray up to 60 Gy. The repetitive X-ray irradiation altered the shape of the NRS1 cells, and their size was approximately 2-folds larger than that of non-irradiated cells. Subsequently, ten clones were selected as radioresistant cancer cell lines. These clones could be categorized into the following three groups; (1) the shape is approximately the same as the majority of irradiated NRS1, (2) have lost cell-to-cell contact and are spindle-like, and (3) undifferentiated-like form. In this study, we report the character changes due to repetitive X-ray irradiation such as radiosensitivity and DNA repair potency, and the effects of C-ion irradiation on radioresistant cancer cell lines. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第71回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2012-09-21 | |||||
| 日付タイプ | Issued | |||||
