@misc{oai:repo.qst.go.jp:00070913,
 author = {佐藤, 克俊 and 藤田, 英俊 and 今井, 高志 and 下川, 卓志 and 佐藤 克俊 and 藤田 英俊 and 今井 高志 and 下川 卓志},
 month = {Sep},
 note = {Cancer cells that survive repetitive X-ray irradiation tend to acquire radioresistance, but the mechanisms of the acquired radioresistace are unclear. The aim of this study is to investigate the underlying mechanisms of radioresistance and the effectiveness of carbon ion (C-ion) irradiation on the radioresistant cancer cells. To establish radioresistant cancer cell lines, we repeatedly irradiated a mouse squamous cell carcinoma cell line, NRS1, with X-ray up to 60 Gy. The repetitive X-ray irradiation altered the shape of the NRS1 cells, and their size was approximately 2-folds larger than that of non-irradiated cells. Subsequently, ten clones were selected as radioresistant cancer cell lines. These clones could be categorized into the following three groups; (1) the shape is approximately the same as the majority of irradiated NRS1, (2) have lost cell-to-cell contact and are spindle-like, and (3) undifferentiated-like form. In this study, we report the character changes due to repetitive X-ray irradiation such as radiosensitivity and DNA repair potency, and the effects of C-ion irradiation on radioresistant cancer cell lines., 第71回日本癌学会学術総会},
 title = {Ｘ線照射後の放射線抵抗性がん細胞株に対する炭素イオン線照射の効果},
 year = {2012}
}