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マウス潰瘍性大腸炎モデルの粘膜再生過程における遺伝子発現解析
https://repo.qst.go.jp/records/70911
https://repo.qst.go.jp/records/70911d41330a8-77a2-4849-94bc-eabc3f368051
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-09-25 | |||||
| タイトル | ||||||
| タイトル | マウス潰瘍性大腸炎モデルの粘膜再生過程における遺伝子発現解析 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
森岡, 孝満
× 森岡, 孝満× 柿沼, 志津子× 臺野, 和広× 西村, まゆみ× 今岡, 達彦× 吉見, 直己× 島田, 義也× 森岡 孝満× 柿沼 志津子× 臺野 和広× 西村 まゆみ× 今岡 達彦× 吉見 直己× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ulcerative colitis is a chronic inflammatory disease, which is characterized by cycles of mucosal ulceration accompanied by necrosis and regeneration of colonic mucosa. This necrosis-regeneration cycle would in theory be linked to neoplastic transformation of normal mucosal epithelia. However, the detailed mechanisms are still not fully understood. In this study, ulcerative colitis was induced in six-week-old C57BL/6J male mice by administering dextran sodium sulfate (DSS) for 7 days. Up until 3 weeks after DSS treatment, we examined temporal changes in gene expression during the mucosal regeneration process by microarray analysis. In addition, expression patterns for several interesting genes were independently confirmed by real-time quantitative RT-PCR. Differentially expressed genes were classified into 4 clusters with distinct expression patterns during mucosal regeneration by K-means clustering. Intriguingly, several genes associated with human colon cancer were strongly up-regulated during regeneration process; hence, these genes may be related with colon carcinogenesis in a repeated DSS-induced colitis model. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第71回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2012-09-21 | |||||
| 日付タイプ | Issued | |||||
