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The effect of C-ion irradiation on metastatic potential of tumor cell lines
https://repo.qst.go.jp/records/70843
https://repo.qst.go.jp/records/70843976aa8cf-7021-4056-84a1-539c4e5138c6
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-08-06 | |||||
| タイトル | ||||||
| タイトル | The effect of C-ion irradiation on metastatic potential of tumor cell lines | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imadome, Kaori
× Imadome, Kaori× Fujita, Mayumi× Endo, Satoshi× Yamada, Shigeru× Imai, Takashi× 今留 香織× 藤田 真由美× 遠藤 悟史× 山田 滋× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Blocking metastatic potential of tumor cells is crucial to improve the clinical outcome of cancer treatment. Carbon-ion (C-ion) radiotherapy offers several advantages over conventional photon radiotherapy with aspects being a high local control. However, it remains to be elucidated whether the local radiotherapy affects the characteristics of subsequently appearing metastatic tumors. Several evidences have shown that the conventional photon irradiation could enhance the metastatic potential of human tumor cells both in vitro and in vivo. On the other hand, C-ion irradiation diminishes the invasive potential of cell lines, but, to date, these studies performed only for 5 cancer cell lines, and thus, further characterization of other tumor cells is required to develop methods for improving the treatment strategies. In this study, we used 20 tumor cell lines including 10 different kinds of human tumors to investigate the effect of C-ion irradiation on metastatic potential of tumor cell lines. Cells were irradiated with C-ion (0 or 2 Gy), and examined the invasive potential by using the transwell chambers containing matrigel on a 6.5-mm filter with a pore size of 8 m. Here we show that 9 cell lines resulted in over 30 % reduction in invasiveness by C-ion irradiation, whereas two cell lines, SF-126 and Caski resulted in induction of invasiveness. Further investigation is needed to clarify the mechanisms of C-ion induced invasiveness found in minority of tumor cells. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 34th Annual Meeting of the Molecular Biology Society of Japan(MBSJ2011) | |||||
| 発表年月日 | ||||||
| 日付 | 2011-12-16 | |||||
| 日付タイプ | Issued | |||||
