@misc{oai:repo.qst.go.jp:00070843,
 author = {Imadome, Kaori and Fujita, Mayumi and Endo, Satoshi and Yamada, Shigeru and Imai, Takashi and 今留 香織 and 藤田 真由美 and 遠藤 悟史 and 山田 滋 and 今井 高志},
 month = {Dec},
 note = {Blocking metastatic potential of tumor cells is crucial to improve the clinical outcome of cancer treatment. Carbon-ion (C-ion) radiotherapy offers several advantages over conventional photon radiotherapy with aspects being a high local control. However, it remains to be elucidated whether the local radiotherapy affects the characteristics of subsequently appearing metastatic tumors. Several evidences have shown that the conventional photon irradiation could enhance the metastatic potential of human tumor cells both in vitro and in vivo. On the other hand, C-ion irradiation diminishes the invasive potential of cell lines, but, to date, these studies performed only for 5 cancer cell lines, and thus, further characterization of other tumor cells is required to develop methods for improving the treatment strategies. In this study, we used 20 tumor cell lines including 10 different kinds of human tumors to investigate the effect of C-ion irradiation on metastatic potential of tumor cell lines. Cells were irradiated with C-ion (0 or 2 Gy), and examined the invasive potential by using the transwell chambers containing matrigel on a 6.5-mm filter with a pore size of 8 m. Here we show that 9 cell lines resulted in over 30 % reduction in invasiveness by C-ion irradiation, whereas two cell lines, SF-126 and Caski resulted in induction of invasiveness. Further investigation is needed to clarify the mechanisms of C-ion induced invasiveness found in minority of tumor cells., 34th Annual Meeting of the Molecular Biology Society of Japan(MBSJ2011)},
 title = {The effect of C-ion irradiation on metastatic potential of tumor cell lines},
 year = {2011}
}